Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 23, Pages 26790-26799Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c06725
Keywords
enzyme; matrix barrier; photothermal microneedle; synergetic therapy; melanoma
Funding
- National Natural Science Foundation of China [32030061, 51772316, 81701267]
- Key Program for Basic Research of Shanghai [19JC1415600]
- Development Project of Shanghai Peak Disciplines-Integrative Medicine of The Institutes of Integrative Medicine of Fudan University [20150407]
- Opening Project of State Key Laboratory of High-Performance Ceramics and Superfine Microstructure [SKL201908SIC]
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This study presents an innovative approach using dissolving microneedles for synergetic photothermal therapy and immune therapy, delivering polymer nanoparticles and immune adjuvant deep into the tumor to activate immune cells and enhance T-cell immune response for inhibition of tumor growth and metastasis.
For melanoma with high lethality and metastasis rate, traditional therapy has limited effects; local photothermal therapy (PTT) synergetic with immune therapy for cancer treatment can perhaps improve the situation. However, because of the natural existence of the tumor matrix barrier, the penetration depth of drugs and immune cells often dampens the efficacy of cancer treatment. Herein, we report an innovative synergetic PTT and immune therapy through dissolving microneedles for the codelivery of the hyaluronidase-modified semiconductor polymer nanoparticles containing poly(cyclopentadithiophene-alt-benzothiadiazole) and immune adjuvant polyinosinic-polycytidylic acid (PIC). Benefiting from the dissolution of an extracellular matrix of hyaluronidase, the semiconductor polymer nanoparticles and PIC penetrate the tumor deeply, under synergetic therapy with PTT, activating the immune cells and enhancing the T-cell immune response for inhibition of tumor growth and metastasis. This study provides a promising platform for effective melanoma treatment and a novel strategy to overcome the stromal barrier.
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