A Narrative Review of Gut-Muscle Axis and Sarcopenia: The Potential Role of Gut Microbiota

Sarcopenia is a multifactorial disease related to aging, chronic inflammation, insufficient nutrition, and physical inactivity. Previous studies have suggested that there is a relationship between sarcopenia and gut microbiota,namely, the gut-muscle axis. The present review highlights that the gut microbiota can affect muscle mass and muscle function from inflammation and immunity,substance and energy metabolism, endocrine and insulin sensitivity, etc., directly or indirectly establishing a connection with sarcopenia, thereby realizing the gut-muscle axis.

Automated summary

This review highlights the relationship between gut microbiota and muscle mass/function, indicating the establishment of the gut-muscle axis and its impact on sarcopenia. The gut microbiota can influence muscle health through various pathways such as inflammation, metabolism, and hormone sensitivity.