Journal
PHOTONICS
Volume 8, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/photonics8040111
Keywords
optical coherence elastography; biomechanics; stiffness; elasticity; cornea
Categories
Funding
- National Institutes of Health [R01EY022362, R01EY030063, P30EY007551]
Ask authors/readers for more resources
The study demonstrated the application of compression-based optical coherence elastography in measuring the biomechanical properties of the cornea under various conditions, showing a significant increase in corneal stiffness with increased IOP and corneal collagen crosslinking. The results emphasized the reliability of this technique in assessing corneal biomechanical properties and its potential for clinical applications.
Assessing the biomechanical properties of the cornea is crucial for detecting the onset and progression of eye diseases. In this work, we demonstrate the application of compression-based optical coherence elastography (OCE) to measure the biomechanical properties of the cornea under various conditions, including validation in an in situ rabbit model and a demonstration of feasibility for in vivo measurements. Our results show a stark increase in the stiffness of the corneas as IOP was increased. Moreover, UV-A/riboflavin corneal collagen crosslinking (CXL) also dramatically increased the stiffness of the corneas. The results were consistent across 4 different scenarios (whole CXL in situ, partial CXL in situ, whole CXL in vivo, and partial CXL in vivo), emphasizing the reliability of compression OCE to measure corneal biomechanical properties and its potential for clinical applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available