4.7 Review

Basic and Preclinical Research for Personalized Medicine

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease

Jaydeep Sidhaye et al.

Summary: Brain organoids provide a valuable tool for studying aspects of human brain development and diseases in vitro. Various brain organoid techniques offer bioassays for investigating new phenotypes associated with human brain disorders that are difficult to study in traditional monolayer cultures. Brain organoids have proven to be particularly useful for studying phenomena and diseases related to neural progenitor morphology, survival, proliferation, and differentiation.

CELL DEATH AND DIFFERENTIATION (2021)

Article Respiratory System

Correction of CFTR function in intestinal organoids to guide treatment of cystic fibrosis

Anabela S. Ramalho et al.

Summary: In patients with CF, CFTR function in intestinal organoids correlates closely with sweat chloride values, and the rescue of CFTR function by CFTR modulators in organoids is tightly associated with improvements in lung function and sweat chloride levels reported in clinical trials. Candidate genotypes for modulator therapy have been identified based on organoid results, suggesting that organoids may serve as a potential in vitro model to guide precision medicine for patients with rare CFTR mutations.

EUROPEAN RESPIRATORY JOURNAL (2021)

Review Cell & Tissue Engineering

Advances in preclinical hematopoietic stem cell models and possible implications for improving therapeutic transplantation

Ellen Fraint et al.

Summary: Hematopoietic stem cell transplantation is a treatment for various hematologic diseases, but challenges remain in expanding HSCs ex vivo, finding immunologically-matched donors, and reducing infection risk during engraftment. Understanding HSC specification, regulation and differentiation in preclinical models is crucial for enhancing the therapeutic utility of HSCT.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

Modeling Alzheimer's disease with iPSC-derived brain cells

Jay Penney et al.

MOLECULAR PSYCHIATRY (2020)

Review Biochemistry & Molecular Biology

Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing

Loubna Mazini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Oncology

Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline

Panagiotis A. Konstantinopoulos et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Multidisciplinary Sciences

Improved protein structure prediction using potentials from deep learning

Andrew W. Senior et al.

NATURE (2020)

Review Neurosciences

The future of stem cell therapies for Parkinson disease

Malin Parmar et al.

NATURE REVIEWS NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

Strategies for Engineering and Rewiring Kinase Regulation

James W. McCormick et al.

TRENDS IN BIOCHEMICAL SCIENCES (2020)

Review Biotechnology & Applied Microbiology

Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy

Abdelkrim Hmadcha et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Multidisciplinary Sciences

In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets

Scott C. Vermilyea et al.

SCIENTIFIC REPORTS (2020)

Review Biochemistry & Molecular Biology

Recent Overview of the Use of iPSCs Huntington's Disease Modeling and Therapy

Maria Csobonyeiova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cell & Tissue Engineering

Amniotic MSCs reduce pulmonary fibrosis by hampering lung B-cell recruitment, retention, and maturation

Anna Cargnoni et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

Review Biochemical Research Methods

Mesenchymal Stem Cell-Derived Exosomes for Effective Cartilage Tissue Repair and Treatment of Osteoarthritis

Young Guk Kim et al.

BIOTECHNOLOGY JOURNAL (2020)

Article Biochemistry & Molecular Biology

GLI1 and AXIN2 Are Distinctive Markers of Human Calvarial Mesenchymal Stromal Cells in Nonsyndromic Craniosynostosis

Lorena Di Pietro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, Research & Experimental

Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies

Kanae Kawai et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

Review Biochemistry & Molecular Biology

Single-cell transcriptomics in cancer: computational challenges and opportunities

Jean Fan et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Review Cell & Tissue Engineering

Inflammatory bowel disease: Therapeutic limitations and prospective of the stem cell therapy

Rangnath Mishra et al.

WORLD JOURNAL OF STEM CELLS (2020)

Review Cell Biology

Genetic Engineering as a Strategy to Improve the Therapeutic Efficacy of Mesenchymal Stem/Stromal Cells in Regenerative Medicine

Patricia Kauanna Fonseca Damasceno et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Cell Biology

Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration

Georgy D. Sagaradze et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Cell & Tissue Engineering

Mesenchymal stem cells: amazing remedies for bone and cartilage defects

Parisa Kangari et al.

STEM CELL RESEARCH & THERAPY (2020)

Review Biotechnology & Applied Microbiology

Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature

Antonietta Rosa Silini et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Review Cell Biology

Large animal ischemic stroke models: replicating human stroke pathophysiology

Erin E. Kaiser et al.

NEURAL REGENERATION RESEARCH (2020)

Review Oncology

Tumor Functional Heterogeneity Unraveled by scRNA-seq Technologies

Laura Gonzalez-Silva et al.

TRENDS IN CANCER (2020)

Review Psychiatry

An Overview of Animal Models Related to Schizophrenia

Ian R. Winship et al.

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE (2019)

Review Genetics & Heredity

Induced pluripotent stem cells in disease modelling and drug discovery

R. Grant Rowe et al.

NATURE REVIEWS GENETICS (2019)

Review Biochemistry & Molecular Biology

Exosomes: biogenesis, biologic function and clinical potential

Yuan Zhang et al.

CELL AND BIOSCIENCE (2019)

Article Cell Biology

Functional Access to Neuron Subclasses in Rodent and Primate Forebrain

Preeti Mehta et al.

CELL REPORTS (2019)

Review Oncology

Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pietro Merli et al.

CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2019)

Article Biochemistry & Molecular Biology

Model validity for preclinical studies in precision medicine: precisely how precise do we need to be?

Abigail L. D. Tadenev et al.

MAMMALIAN GENOME (2019)

Review Neurosciences

Editing the Central Nervous System Through CRISPR/Cas9 Systems

Agustin Cota-Coronado et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

Atypical behaviour and connectivity in SHANK3-mutant macaques

Yang Zhou et al.

NATURE (2019)

Review Cell & Tissue Engineering

Epidermal stem cells in wound healing and their clinical applications

Ronghua Yang et al.

STEM CELL RESEARCH & THERAPY (2019)

Review Cell Biology

Mesenchymal Stem Cell Migration and Tissue Repair

Xiaorong Fu et al.

CELLS (2019)

Article Genetics & Heredity

Synergistic effects of common schizophrenia risk variants

Nadine Schrode et al.

NATURE GENETICS (2019)

Review Biochemistry & Molecular Biology

Animal Models for Parkinson's Disease Research: Trends in the 2000s

Kyohei Kin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cell Biology

PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells

Sylvie M. Noordermeer et al.

TRENDS IN CELL BIOLOGY (2019)

Article Cell & Tissue Engineering

Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche

Yu Kitadate et al.

CELL STEM CELL (2019)

Article Biochemical Research Methods

Systemic AAV vectors for widespread and targeted gene delivery in rodents

Rosemary C. Challis et al.

NATURE PROTOCOLS (2019)

Review Virology

Viral Delivery Systems for CRISPR

Christine L. Xu et al.

VIRUSES-BASEL (2019)

Review Oncology

Tumour heterogeneity and resistance to cancer therapies

Ibiayi Dagogo-Jack et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Chemistry, Multidisciplinary

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics

Ibraheem Ali et al.

CHEMICAL REVIEWS (2018)

Review Biochemistry & Molecular Biology

Disease Modeling Using 3D Organoids Derived from Human Induced Pluripotent Stem Cells

Beatrice Xuan Ho et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Oncology

Hematopoietic stem cell transplantation for sickle cell disease: Progress and challenges

Monica L. Hulbert et al.

PEDIATRIC BLOOD & CANCER (2018)

Review Clinical Neurology

Use of CRISPR/Cas9 to model brain diseases

Sen Yan et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2018)

Article Oncology

Cancer Risks for PMS2-Associated Lynch Syndrome

Sanne W. ten Broeke et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

Article Multidisciplinary Sciences

The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy

Fumiko Kusunoki Nakamoto et al.

SCIENTIFIC REPORTS (2018)

Article Geriatrics & Gerontology

Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty

Tobias Winkler et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2018)

Article Gastroenterology & Hepatology

Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids

Shuji Hibiya et al.

JOURNAL OF CROHNS & COLITIS (2017)

Article Cell & Tissue Engineering

Human amnion favours tissue repair by inducing the M1-to-M2 switch and enhancing M2 macrophage features

Marta Magatti et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

Review Biotechnology & Applied Microbiology

Adipose-derived stem cell therapies for bone regeneration

Marta Barba et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2017)

Review Biochemistry & Molecular Biology

Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

Francisco J. Vizoso et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Genetics & Heredity

Stem cell-derived organoids and their application for medical research and patient treatment

Sina Bartfeld et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2017)

Review Biochemistry & Molecular Biology

Editing the genome of hiPSC with CRISPR/Cas9: disease models

Andrew R. Bassett

MAMMALIAN GENOME (2017)

Review Biochemical Research Methods

Methods, Tools and Current Perspectives in Proteogenomics

Kelly V. Ruggles et al.

MOLECULAR & CELLULAR PROTEOMICS (2017)

Article Multidisciplinary Sciences

Regeneration of the entire human epidermis using transgenic stem cells

Tobias Hirsch et al.

NATURE (2017)

Article Biochemical Research Methods

Multimodal profiling of single-cell morphology, electrophysiology, and gene expression using Patch-seq

Cathryn R. Cadwell et al.

NATURE PROTOCOLS (2017)

Article Biochemical Research Methods

Quantitative proteomics: challenges and opportunities in basic and applied research

Olga T. Schubert et al.

NATURE PROTOCOLS (2017)

Article Medicine, General & Internal

Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation

Mark Robson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy

J. R. Mendell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Cell & Tissue Engineering

Extracellular Vesicle-Shuttled mRNA in Mesenchymal Stem Cell Communication

Enrico Ragni et al.

STEM CELLS (2017)

Review Biochemistry & Molecular Biology

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

Devanjali Dutta et al.

TRENDS IN MOLECULAR MEDICINE (2017)

Review Medicine, General & Internal

CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells

Eun Ji Kim et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2017)

Review Medicine, Research & Experimental

Genetic Engineering and Manufacturing of Hematopoietic Stem Cells

Xiuyan Wang et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2017)

Article Multidisciplinary Sciences

Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE

Marie-Christine Birling et al.

SCIENTIFIC REPORTS (2017)

Review Cell Biology

Rodent models in Down syndrome research: impact and future opportunities

Yann Herault et al.

DISEASE MODELS & MECHANISMS (2017)

Review Biochemistry & Molecular Biology

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future

Nicholas McGranahan et al.

Article Biochemistry & Molecular Biology

Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

Hui Zhang et al.

Article Critical Care Medicine

Protection of Brain Injury by Amniotic Mesenchymal Stromal Cell-Secreted Metabolites

Francesca Pischiutta et al.

CRITICAL CARE MEDICINE (2016)

Review Developmental Biology

Dishing out mini-brains: Current progress and future prospects in brain organoid research

Iva Kelava et al.

DEVELOPMENTAL BIOLOGY (2016)

Review Endocrinology & Metabolism

Minireview: Genome Editing of Human Pluripotent Stem Cells for Modeling Metabolic Disease

Haojie Yu et al.

MOLECULAR ENDOCRINOLOGY (2016)

Article Biochemistry & Molecular Biology

Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology

C. Bardy et al.

MOLECULAR PSYCHIATRY (2016)

Article Biotechnology & Applied Microbiology

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

Benjamin E. Deverman et al.

NATURE BIOTECHNOLOGY (2016)

Review Biology

CRISPR-Cas: biology, mechanisms and relevance

Frank Hille et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2016)

Review Cell & Tissue Engineering

Tweaking Mesenchymal Stem/Progenitor Cell Immunomodulatory Properties with Viral Vectors Delivering Cytokines

Paola Quaranta et al.

STEM CELLS AND DEVELOPMENT (2016)

Review Cell & Tissue Engineering

Mechanisms of mesenchymal stem/stromal cell function

Jeffrey L. Spees et al.

STEM CELL RESEARCH & THERAPY (2016)

Review Pharmacology & Pharmacy

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

Daniel J. Urban et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 (2015)

Review Neurosciences

Diagnostic and therapeutic potentials of exosomes in CNS diseases

Ivana Kawikova et al.

BRAIN RESEARCH (2015)

Article Gastroenterology & Hepatology

Human Placenta-derived Cells (PDA-001) for the Treatment of Moderate-to-severe Crohn's Disease: A Phase 1b/2a Study

Gil Y. Melmed et al.

INFLAMMATORY BOWEL DISEASES (2015)

Article Medicine, General & Internal

Association of Type and Location of BRCA1 and BRCA2 Mutations With Risk of Breast and Ovarian Cancer

Timothy R. Rebbeck et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Article Neurosciences

Osteogenic and Neurogenic Stem Cells in Their Own Place: Unraveling Differences and Similarities Between Niches

Wanda Lattanzi et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Review Biotechnology & Applied Microbiology

The long path of human placenta, and its derivatives, in regenerative medicine

Antonietta R. Silini et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2015)

Article Genetics & Heredity

Annotating DNA Variants Is the Next Major Goal for Human Genetics

Garry R. Cutting

AMERICAN JOURNAL OF HUMAN GENETICS (2014)

Review Biochemistry & Molecular Biology

Development and Applications of CRISPR-Cas9 for Genome Engineering

Patrick D. Hsu et al.

Article Medicine, General & Internal

Breast-Cancer Risk in Families with Mutations in PALB2

A. C. Antoniou et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Gastroenterology & Hepatology

Safety and Tolerability of Human Placenta-Derived Cells (PDA001) in Treatment-Resistant Crohn's Disease: A Phase 1 Study

Lloyd Mayer et al.

INFLAMMATORY BOWEL DISEASES (2013)

Review Chemistry, Analytical

Unraveling the different proteomic platforms

Irene Messana et al.

JOURNAL OF SEPARATION SCIENCE (2013)

Article Multidisciplinary Sciences

Cerebral organoids model human brain development and microcephaly

Madeline A. Lancaster et al.

NATURE (2013)

Article Multidisciplinary Sciences

Rational design of a ligand-controlled protein conformational switch

Onur Dagliyan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell & Tissue Engineering

Phenotypic and Functional Characterization of Mesenchymal Stem Cells from Chorionic Villi of Human Term Placenta

M. H. Abumaree et al.

STEM CELL REVIEWS AND REPORTS (2013)

Review Pharmacology & Pharmacy

Personalized nanomedicine advancements for stem cell tracking

Miroslaw Janowski et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Article Medicine, General & Internal

Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer

Kelly L. Bolton et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

Article Biochemical Research Methods

Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics

Amelia C. Peterson et al.

MOLECULAR & CELLULAR PROTEOMICS (2012)

Article Multidisciplinary Sciences

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jinek et al.

SCIENCE (2012)

Review Oncology

Intra-tumour heterogeneity: a looking glass for cancer?

Andriy Marusyk et al.

NATURE REVIEWS CANCER (2012)

Article Oncology

PARP Inhibitor Treatment in Ovarian and Breast Cancer

[Anonymous]

CURRENT PROBLEMS IN CANCER (2011)

Article Medicine, Research & Experimental

Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua Jiang et al.

Frontiers of Medicine (2011)

Article Oncology

Germline BRCA Mutations Denote a Clinicopathologic Subset of Prostate Cancer

David J. Gallagher et al.

CLINICAL CANCER RESEARCH (2010)

Article Medical Laboratory Technology

A simple liquid chromatography-tandem mass spectrometry method for urinary free cortisol analysis: suitable for routine purpose

Silvia Persichilli et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2010)

Article Biotechnology & Applied Microbiology

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

Peter O. Bauer et al.

NATURE BIOTECHNOLOGY (2010)

Editorial Material Medicine, General & Internal

The Path to Personalized Medicine

Margaret A. Hamburg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Cell & Tissue Engineering

Transplantation of Allogeneic and Xenogeneic Placenta-Derived Cells Reduces Bleomycin-Induced Lung Fibrosis

Anna Cargnoni et al.

CELL TRANSPLANTATION (2009)

Article Clinical Neurology

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

C. W. Christine et al.

NEUROLOGY (2009)

Article Medicine, General & Internal

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers.

Peter C. Fong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Multidisciplinary Sciences

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

Chunaram Choudhary et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

Kazutoshi Takahashi et al.

Article Biochemistry & Molecular Biology

Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells

Fulvio Mavilio et al.

NATURE MEDICINE (2006)

Article Multidisciplinary Sciences

Alzheimer's disease β-amyloid peptides are released in association with exosomes

Lawrence Rajendran et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Neurosciences

Millisecond-timescale, genetically targeted optical control of neural activity

ES Boyden et al.

NATURE NEUROSCIENCE (2005)

Review Oncology

The Fanconi anaemia BRCA pathway

AD D'Andrea et al.

NATURE REVIEWS CANCER (2003)

Article Biochemistry & Molecular Biology

BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

PL Welcsh et al.

HUMAN MOLECULAR GENETICS (2001)

Article Biochemistry & Molecular Biology

BRCA2 is required for homology-directed repair of chromosomal breaks

ME Moynahan et al.

MOLECULAR CELL (2001)