Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/jpm11030225
Keywords
COVID-19; heart failure; inflammation; cytokine storm; transthoracic echocardio-graphy; left ventricular systolic dysfunction; diastolic dysfunction
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This study found that some COVID-19 patients without a history of cardiovascular diseases still experienced alterations in left ventricular systolic function and diastolic dysfunction in the weeks following discharge. These changes may be linked to elevated myocardial necrosis markers during the acute phase of the illness.
(1) Background: Coronavirus infection (Covid-19) has emerged as a severe medical condition, associated with high pulmonary morbidity and often with cardiovascular (CV) complications. This study aims to evidence the persistence of left ventricular (LV) systolic function (LV-SF) alterations and diastolic dysfunction (DD) in COVID-19 patients without history of cardiovascular (CV) diseases by transthoracic echocardiography (TTE). (2) Methods: 125 patients, aged under 55 years, hospitalized during the first outbreak of Covid-19 for moderate pneumonia, underwent a comprehensive cardiologic examination and TTE at 6-10 weeks after discharge. Their initial in-hospital laboratory data and thorax computer tomography (TCT) were accessed from the electronic database of the hospital. (3) Results: with TTE, we documented alterations of LV-SF and DD in 8.8% of patients and in 16.8% only patterns of DD, statistically correlated with the initial levels of creatin-kinase (CK-MB) and inflammatory factors. Multivariate regression analysis evidenced that CK-MB levels, age, and body mass index (BMI) are responsible for 65% of LV-SF decrease. (4) Conclusions: Alterations of LV-SF and DD are frequent in post-acute COVID-19 infection and are responsible for the persistence of symptoms. Elevated myocardial necrosis markers during the acute phase seem to predict subsequent alteration of cardiac performance.
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