Proton Therapy for Partial Breast Irradiation: Rationale and Considerations

In an era of continued advancements in personalized medicine for the treatment of breast cancer, select patients with early stage breast cancer may be uniquely poised to benefit from partial breast irradiation (PBI) delivered with proton therapy. PBI presents an opportunity to improve quality of life during treatment with a significantly shorter treatment duration. By targeting less non-target breast tissue, excess radiation exposure and resulting toxicities are also reduced. Proton therapy represents a precision radiotherapy technology that builds on these advantages by further limiting the normal tissue exposure to unnecessary radiation dose not only to uninvolved breast tissue but also the underlying thoracic organs including the heart and lungs. Herein, we present a concise review of the rationale for the use of proton therapy for PBI, evidence available to date, and practical considerations in the implementation and use of proton therapy for this indication.

Automated summary

Partial breast irradiation (PBI) delivered with proton therapy offers a shorter treatment duration and reduced toxicities, targeting less non-target breast tissue and limiting unnecessary radiation dose to thoracic organs. Proton therapy is a precision radiotherapy technology that further limits normal tissue exposure to improve quality of life for early stage breast cancer patients.