Journal
ISCIENCE
Volume 24, Issue 5, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.isci.2021.102443
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Funding
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2015-0632]
- Canadian Institutes of Health Research
- Canada Research Chair in Biomaterials and Stem Cells in Ophthalmology
- New Frontiers in Research Fund-Exploration Stream
- Government of Ontario
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Biofilm formation is linked to infections and antibiotic resistance, making it crucial for the development of antibiofilm treatments. While decades of research have contributed to in vitro and in vivo biofilm models, there is still no universally applicable model available.
Biofilm formation in living organisms is associated to tissue and implant infections, and it has also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm development and being able to mimic such processes is vital for the successful development of antibiofilm treatments and therapies. Several decades of research have contributed to building the foundation for developing in vitro and in vivo biofilm models. However, no such thing as an all fit'' in vitro or in vivo biofilm models is currently available. In this review, in addition to presenting an updated overview of biofilm formation, we critically revise recent approaches for the improvement of in vitro and in vivo biofilm models.
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