4.6 Article

Activated IL-6 signaling contributes to the pathogenesis of, and is a novel therapeutic target for, CALR-mutated MPNs

Related references

Note: Only part of the references are listed.
Editorial Material Hematology

Both sides now: losses and gains of mutant CALR

Ann Mullally

BLOOD (2020)

Review Biochemistry & Molecular Biology

Calnexin cycle - structural features of the ER chaperone system

Guennadi Kozlov et al.

FEBS JOURNAL (2020)

Letter Medicine, General & Internal

Tocilizumab and soluble interleukin-6 receptor in JAK2V617F somatic mutation and myeloproliferative neoplasm

Kasper Monsted Pedersen et al.

ECLINICALMEDICINE (2020)

Review Oncology

Interleukin-6: A Masterplayer in the Cytokine Network

Peter Uciechowski et al.

ONCOLOGY (2020)

Article Hematology

Mutant calreticulin in myeloproliferative neoplasms

Joan How et al.

BLOOD (2019)

Review Oncology

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

Daniel E. Johnson et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Immunology

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

Simon A. Jones et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Medicine, Research & Experimental

Targeting the CALR interactome in myeloproliferative neoplasms

Elodie Pronier et al.

JCI INSIGHT (2018)

Letter Hematology

Ruxolitinib is an effective treatment for CALR-positive patients with myelofibrosis

Paola Guglielmelli et al.

BRITISH JOURNAL OF HAEMATOLOGY (2016)

Review Biotechnology & Applied Microbiology

Functional Roles of Calreticulin in Cancer Biology

Yi-Chien Lu et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Medicine, General & Internal

JAK Inhibitor in CALR-Mutant Myelofibrosis

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

J. Nangalia et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

Thorsten Klampfl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Biochemistry & Molecular Biology

NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells

S. Yoon et al.

ONCOGENE (2012)

Article Pharmacology & Pharmacy

Clinical pharmacology of tocilizumab for the treatment of patients with rheumatoid arthritis

Xiaoping Zhang et al.

Expert Review of Clinical Pharmacology (2011)

Review Biochemistry & Molecular Biology

Calreticulin: non-endoplasmic reticulum functions in physiology and disease

Leslie I. Gold et al.

FASEB JOURNAL (2010)