Healthcare Data for Achieving a More Personalized Treatment of Chronic Kidney Disease

Article Biochemistry & Molecular Biology

Gut Microbiome Composition Remains Stable in Individuals with Diabetes-Related Early to Late Stage Chronic Kidney Disease

Ashani Lecamwasam et al.

Summary: Individuals with diabetes and chronic kidney disease show gut dysbiosis, with Firmicutes and Bacteroidetes as predominant phyla. The relative abundance of these gut microbes does not change across the early and late stages of diabetic chronic kidney disease, suggesting it is an early event in disease development.

BIOMEDICINES (2021)

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Review Biochemistry & Molecular Biology

Sarcopenia in Chronic Kidney Disease: Focus on Advanced Glycation End Products as Mediators and Markers of Oxidative Stress

Elena Dozio et al.

Summary: Sarcopenia in chronic kidney disease is independently associated with morbidity and mortality, with advanced glycation end products (AGE) playing a key role in its pathogenesis. The imbalance of oxidant/antioxidant capacities in CKD patients leads to AGE accumulation, which can promote CKD progression and related complications by inducing inflammation and fibrosis. Understanding the link between AGE and oxidative stress in the onset of sarcopenia may help identify new markers for disease progression and therapeutic targets.

BIOMEDICINES (2021)

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Article Medicine, General & Internal

Clinical Profile, Pharmacological Treatment, and Predictors of Death Among Hospitalized COVID-19 Patients With Acute Kidney Injury: A Population-Based Registry Analysis

Eduardo Gutierrez-Abejon et al.

Summary: This study found a high incidence of AKI among COVID-19 patients, with comorbidities including hypertension, cardiovascular disease, diabetes, and chronic kidney disease, and the use of multiple medications. Compared to patients without AKI, those with AKI had a significantly higher mortality rate, with predictors of hospital death including oxygen delivery and ventilation needs, treatment with steroids or anti-SIRS drugs, occurrence of SARS, and SIRS.

FRONTIERS IN MEDICINE (2021)

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Article Biochemistry & Molecular Biology