Journal
BIOACTIVE MATERIALS
Volume 6, Issue 4, Pages 1189-1200Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.10.007
Keywords
Magnesium; Tantalum; Poly(ether imide); Bio-functionalized coating; Biodegradable orthopedic implants
Funding
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI18C0493]
- Korea Health Promotion Institute [HI18C0493020021] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [5199990514442] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The study modified the physical and chemical properties of PEI-coated magnesium implants by introducing biologically compatible tantalum, which significantly enhanced bone tissue affinity and osseointegration capability. Results from a rabbit femur study indicated promising potential for achieving early mechanical fixation and long-term success in biodegradable orthopedic implant applications with Ta/PEI-coated magnesium.
Poly(ether imide) (PEI) has shown satisfactory corrosion protection capability with good adhesion strength as a coating for magnesium (Mg), a potential candidate of biodegradable orthopedic implant material. However, its innate hydrophobic property causes insufficient osteoblast affinity and a lack of osseointegration. Herein, we modify the physical and chemical properties of a PEI-coated Mg implant. A plasma immersion ion implantation technique is combined with direct current (DC) magnetron sputtering to introduce biologically compatible tantalum (Ta) onto the surface of the PEI coating. The PEI-coating layer is not damaged during this process owing to the extremely short processing time (30 s), retaining its high corrosion protection property and adhesion stability. The Ta-implanted layer (roughly 10-nm-thick) on the topmost PEI surface generates long-term surface hydmphilicity and favorable surface conditions for pre-osteoblasts to adhere, proliferate, and differentiate. Furthermore, in a rabbit femur study, the Ta/PEI-coated Mg implant demonstrates significantly enhanced bone tissue affinity and osseointegration capability. These results indicate that Ta/PEI-coated Mg is promising for achieving early mechanical fixation and long-term success in biodegradable orthopedic implant applications.
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