Journal
BIOACTIVE MATERIALS
Volume 6, Issue 5, Pages 1230-1241Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.10.017
Keywords
Zn scaffold; RGO; Laser additive manufacturing; Mechanical performance; Cell behavior
Funding
- Natural Science Foundation of China [51935014, 81871494, 81871498]
- JiangXi Provincial Natural Science Foundation of China [20192ACB20005, 2020ACB214004, 20202BAB214011]
- Provincial Key R&D Projects of Jiangxi [20201BBE51012]
- Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme
- Project of Hunan Provincial Science and Technology Plan [2017RS3008]
- Shenzhen Science and Technology Plan Project [JCYJ20170817112445033]
- Innovation Team Project on University of Guangdong Province [2018GKCXTD001]
- Technology Innovation Platform Project of Shenzhen Institute of Information Technology [PT2020E002]
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This study demonstrated the great potential of using reduced graphene oxide (RGO) as reinforcement in zinc scaffold to enhance mechanical performance and cell behavior, making it a promising material for bone repair applications.
Zinc (Zn) possesses desirable degradability and favorable biocompatibility, thus being recognized as a promising bone implant material. Nevertheless, the insufficient mechanical performance limits its further clinical application. In this study, reduced graphene oxide (RGO) was used as reinforcement in Zn scaffold fabricated via laser additive manufacturing. Results showed that the homogeneously dispersed RGO simultaneously enhanced the strength and ductility of Zn scaffold. On one hand, the enhanced strength was ascribed to (i) the grain refinement caused by the pinning effect of RGO, (ii) the efficient load shift due to the huge specific surface area of RGO and the favorable interface bonding between RGO and Zn matrix, and (iii) the Orowan strengthening by the homogeneously distributed RGO. On the other hand, the improved ductility was owing to the RGO-induced random orientation of grain with texture index reducing from 20.5 to 7.3, which activated more slip systems and provided more space to accommodate dislocation. Furthermore, the cell test confirmed that RGO promoted cell growth and differentiation. This study demonstrated the great potential of RGO in tailoring the mechanical performance and cell behavior of Zn scaffold for bone repair.
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