Journal
ACS OMEGA
Volume 6, Issue 20, Pages 13391-13397Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.1c01448
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Funding
- Vietnam National Foundation for Science and Technology Development (NAFOSTED)
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Anthraquinones isolated from Paederia plants have various pharmacological activities, including antioxidant and anti-inflammatory properties, with particularly effective superoxide anion scavenging activity in aqueous solution.
Anthraquinones (ANQs) isolated from Paederia plants are known to have antidiarrheal, antitussive, anthelmintic, analgesic, anti-inflammatory, antihyperlipidemic, antihyperglycaemic, and antimicrobial activities. The antioxidant properties were also noted but not confirmed thus far. In this study, the superoxide and hydroperoxide radical scavenging activities of six ANQs were evaluated using a computational approach. The results suggest that the ANQs exhibit low HOO center dot antiradical activity in all environments, including the gas phase (k < 10(2) M-1 s(-1)). In contrast, the ANQs might exert excellent O-2(center dot-) radical scavenging activity, particularly in aqueous solution. The rate constants of the superoxide anion scavenging in water (at pH = 7.4) range from 3.42 x 10(6) to 3.70 x 10(8) M-1 s(-1). Compared with typical antioxidants such as ascorbic acid and quercetin, the superoxide anion scavenging activity of ANQs is significantly higher. Thus, the ANQs are promising O-2(center dot-) radical scavengers in polar media.
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