A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior

Research investigating the neural substrates underpinning parental behaviour has recently gained momentum. Particularly, the hypothalamic medial preoptic area (MPOA) has been identified as a crucial region for parenting. The current study conducted a scientometric analysis of publications from 1 January 1972 to 19 January 2021 using CiteSpace software to determine trends in the scientific literature exploring the relationship between MPOA and parental behaviour. In total, 677 scientific papers were analysed, producing a network of 1509 nodes and 5498 links. Four major clusters were identified: C-Fos Expression, Lactating Rat, Medial Preoptic Area Interaction and Parental Behavior. Their content suggests an initial trend in which the properties of the MPOA in response to parental behavior were studied, followed by a growing attention towards the presence of a brain network, including the reward circuits, regulating such behavior. Furthermore, while attention was initially directed uniquely to maternal behavior, it has recently been extended to the understanding of paternal behaviors as well. Finally, although the majority of the studies were conducted on rodents, recent publications broaden the implications of previous documents to human parental behavior, giving insight into the mechanisms underlying postpartum depression. Potential directions in future works were also discussed.

Automated summary

Research on the neural substrates of parental behavior, particularly focusing on the hypothalamic medial preoptic area (MPOA), has gained momentum. A scientometric analysis of publications from 1972 to 2021 revealed a trend of initially studying MPOA's response to parental behavior and later exploring the brain network regulating such behavior, including reward circuits. The focus has expanded from maternal behavior to understanding paternal behaviors as well.