Journal
BRAIN SCIENCES
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/brainsci11050659
Keywords
functional imaging; avoidance learning; acquisition; memory retrieval; prefrontal cortex; limbic system
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The study used SPECT to assess brain activation patterns in freely behaving rats during different stages of active avoidance learning, identifying specific prefrontal cortical, sensory, and limbic circuits involved in the acquisition and retrieval phases of the two-way avoidance learning task.
Active avoidance learning is a complex form of aversive feedback learning that in humans and other animals is essential for actively coping with unpleasant, aversive, or dangerous situations. Since the functional circuits involved in two-way avoidance (TWA) learning have not yet been entirely identified, the aim of this study was to obtain an overall picture of the brain circuits that are involved in active avoidance learning. In order to obtain a longitudinal assessment of activation patterns in the brain of freely behaving rats during different stages of learning, we applied single-photon emission computed tomography (SPECT). We were able to identify distinct prefrontal cortical, sensory, and limbic circuits that were specifically recruited during the acquisition and retrieval phases of the two-way avoidance learning task.
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