Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds

Environmental factors, particularly diet, are considered central to the pathogenesis of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. In particular, the Westernization of diet, characterized by high intake of animal protein, saturated fat, and refined carbohydrates, has been shown to contribute to the development and progression of IBD. During the last decade, soybean, as well as soy-derived bioactive compounds (e.g., isoflavones, phytosterols, Bowman-Birk inhibitors) have been increasingly investigated because of their anti-inflammatory properties in animal models of IBD. Herein we provide a scoping review of the most studied disease mechanisms associated with disease induction and progression in IBD rodent models after feeding of either the whole food or a bioactive present in soybean.

Automated summary

This passage discusses the role of environmental factors, particularly diet, in the pathogenesis of inflammatory bowel diseases, with a focus on the Westernization of diet and its contribution to IBD. It also highlights the increasing research on the anti-inflammatory properties of soybean and its bioactive compounds in animal models of IBD.