☆ 4.5 Review

Diverse Immunological Factors Influencing Pathogenesis in Patients with COVID-19: A Review on Viral Dissemination, Immunotherapeutic Options to Counter Cytokine Storm and Inflammatory Responses

PATHOGENS (2021)

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Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study

Lei Pan et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2020)

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Digestive Symptoms in COVID-19 Patients With Mild Disease Severity: Clinical Presentation, Stool Viral RNA Testing, and Outcomes

Chaoqun Han et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2020)

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Letter Oncology

Tocilizumab, an anti-IL-6 receptor antibody, to treat COVID-19-related respiratory failure: a case report

J. -M. Michot et al.

ANNALS OF ONCOLOGY (2020)

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

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Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Meijuan Zheng et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19

Hin Chu et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

Chuan Qin et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

Mehmet Soy et al.

CLINICAL RHEUMATOLOGY (2020)

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Effect of Gastrointestinal Symptoms in Patients With COVID-19

Zili Zhou et al.

GASTROENTEROLOGY (2020)

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COVID-19 and immunomodulation in IBD

Markus F. Neurath

GUT (2020)

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Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

Xi Jin et al.

GUT (2020)

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Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

Xiaobo Yang et al.

Lancet Respiratory Medicine (2020)

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A first case of meningitis/encephalitis associated with SARS-Coronavirus-2

Takeshi Moriguchi et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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COVID-19 and stroke-A global World Stroke Organization perspective

Hugh S. Markus et al.

INTERNATIONAL JOURNAL OF STROKE (2020)

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Letter Medicine, General & Internal

Detection of SARS-CoV-2 in Different Types of Clinical Specimens

Wenling Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

Giacomo Grasselli et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Physiology

Let's talk about sex in the context of COVID-19

Luciane H. Gargaglioni et al.

JOURNAL OF APPLIED PHYSIOLOGY (2020)

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Covid-19 and the digestive system

Sunny H. Wong et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Effective treatment of severe COVID-19 patients with tocilizumab

Xiaoling Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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COVID-19: Abnormal liver function tests

Qingxian Cai et al.

JOURNAL OF HEPATOLOGY (2020)

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Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis

Francisco Alejandro Lagunas-Rangel

JOURNAL OF MEDICAL VIROLOGY (2020)

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2019-nCoV/COVID-19-Approaches to Viral Vaccine Development and Preventive Measures

Muhammad Bilal et al.

JOURNAL OF PURE AND APPLIED MICROBIOLOGY (2020)

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25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2

Antonio D'Avolio et al.

NUTRIENTS (2020)

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An update on SARS-CoV-2/COVID-19 with particular reference to its clinical pathology, pathogenesis, immunopathology and mitigation strategies

Kuldeep Dhama et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2020)

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Features of 20133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Annemarie B. Docherty et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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10-MINUTE CONSULTATION Covid-19: a remote assessment in primary care

Trisha Greenhalgh et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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What Other Countries Can Learn From Italy During the COVID-19 Pandemic

Stefania Boccia et al.

JAMA INTERNAL MEDICINE (2020)

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Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

Chaomin Wu et al.

JAMA INTERNAL MEDICINE (2020)

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Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed

Marc Feldmann et al.

LANCET (2020)

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Endothelial cell infection and endotheliitis in COVID-19

Zsuzsanna Varga et al.

LANCET (2020)

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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Liver injury during highly pathogenic human coronavirus infections

Ling Xu et al.

LIVER INTERNATIONAL (2020)

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Impact of sex and gender on COVID-19 outcomes in Europe

Catherine Gebhard et al.

BIOLOGY OF SEX DIFFERENCES (2020)

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Vitamin D deficiency and the COVID-19 pandemic

Patrick Zemb et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2020)

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Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19

Paolo Antonio Ascierto et al.

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The neurological manifestations of COVID-19: a review article

Hamid Reza Niazkar et al.

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Multiorgan and Renal Tropism of SARS-CoV-2

Victor G. Puelles et al.

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Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young

Thomas J. Oxley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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The first, holistic immunological model of COVID-19: Implications for prevention, diagnosis, and public health measures

Paolo Maria Matricardi et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2020)

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Systematic review with meta-analysis: liver manifestations and outcomes in COVID-19

Anand V. Kulkarni et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2020)

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Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China

J. Zhang et al.

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Coronavirus Disease 2019-COVID-19

Kuldeep Dhama et al.

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Immunoinformatics-guided design of an epitope-based vaccine against severe acute respiratory syndrome coronavirus 2 spike glycoprotein

Ahmed Rakib et al.

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Antibody-based immunotherapeutics and use of convalescent plasma to counter COVID-19: advances and prospects

Khan Sharun et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

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Non-invasive Auricular Vagus Nerve Stimulation as a Potential Treatment for Covid19-Originated Acute Respiratory Distress Syndrome

Eugenijus Kaniusas et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Role of Immune Dysregulation in Increased Mortality Among a Specific Subset of COVID-19 Patients and Immune-Enhancement Strategies for Combatting Through Nutritional Supplements

Kosagi-Sharaf Rao et al.

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The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients

Alessandro Marcello et al.

REDOX BIOLOGY (2020)

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The complement system in COVID-19: friend and foe?

Anuja Java et al.

JCI INSIGHT (2020)

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Ruxolitinib Rapidly Reduces Acute Respiratory Distress Syndrome in COVID-19 Disease. Analysis of Data Collection From RESPIRE Protocol

Enrico Capochiani et al.

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Prevalence of Gastrointestinal Symptoms and Fecal Viral Shedding in Patients With Coronavirus Disease 2019 A Systematic Review and Meta-analysis

Sravanthi Parasa et al.

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Serum Cytokine and Chemokine Profile in Relation to the Severity of Coronavirus Disease 2019 in China

Ying Chi et al.

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COVID-19 is an emergent disease of aging

Didac Santesmasses et al.

AGING CELL (2020)

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Complement Inhibition with the C5 Blocker LFG316 in Severe COVID-19

Wioleta M. Zelek et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Cerebrospinal fluid findings in COVID-19 patients with neurological symptoms

Bernhard Neumann et al.

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Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Takuya Sekine et al.

CELL (2020)

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25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor

Shulong Zu et al.

CELL RESEARCH (2020)

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COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

Robert Lorenz Chua et al.

NATURE BIOTECHNOLOGY (2020)

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Single-cell landscape of immunological responses in patients with COVID-19

Ji-Yuan Zhang et al.

NATURE IMMUNOLOGY (2020)

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COVID-19 revisiting inflammatory pathways of arthritis

Georg Schett et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

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Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatment

Swamy Yeleswaram et al.

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Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

Li Runfeng et al.

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COVID-19 and the Immune System

Jan Paces et al.

PHYSIOLOGICAL RESEARCH (2020)

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Immunopathology and immunotherapeutic strategies in severe acute respiratory syndrome coronavirus 2 infection

Synat Keam et al.

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Liver injury in severe COVID-19 infection: current insights and challenges

Nurshad Ali et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2020)

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COVID-19-Recent advancements in identifying novel vaccine candidates and current status of upcoming SARS-CoV-2 vaccines

Mohd Iqbal Yatoo et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

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Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19

Xiuhong Zhang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Broad and strong memory CD4+and CD8+T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Yanchun Peng et al.

NATURE IMMUNOLOGY (2020)

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An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

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Sex-specific association between vitamin D deficiency and COVID-19 mortality in older patients

M. Hars et al.

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Gender differences in COVID-19 attitudes and behavior: Panel evidence from eight countries

Vincenzo Galasso et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

Jan C. Holter et al.

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Pros and cons of corticosteroid therapy for COVID-19 patients

Paula Mattos-Silva et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2020)

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Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive Symptoms

Caihan Duan et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2020)

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Dexamethasone to combat cytokine storm in COVID-19: Clinical trials and preliminary evidence

Khan Sharun et al.

INTERNATIONAL JOURNAL OF SURGERY (2020)

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COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes

Vijaya Anand Arumugam et al.

JOURNAL OF PURE AND APPLIED MICROBIOLOGY (2020)

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Therapeutic Modalities for SARS-Cov-2 (COVID-19): Current Status and Role of Protease Inhibitors to Block Viral Entry Into Host Cells

Sarmad Ahmad Qamar et al.

JOURNAL OF PURE AND APPLIED MICROBIOLOGY (2020)

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SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic

Ali A. Rabaan et al.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2020)

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Recent advances in therapeutic modalities and vaccines to counter COVID-19/SARS-CoV-2

Muhammad Bilal et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

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COVID-19: benefits and risks of passive immunotherapeutics

Ankur Gupta et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

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Coronavirus disease 2019 (COVID-19) in domestic animals and wildlife: advances and prospects in the development of animal models for vaccine and therapeutic research

Khan Sharun et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

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What's Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses

Nirupa Gadi et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Vitamin D and Sex Differences in COVID-19

Maria Teresa Pagano et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Renin Angiotensin System, COVID-19 and Male Fertility: Any Risk for Conceiving?

Lorella Pascolo et al.

MICROORGANISMS (2020)

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A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency

Linda L. Benskin

FRONTIERS IN PUBLIC HEALTH (2020)

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Treatment for COVID-19: An overview

Cristina Stasi et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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COVID-19: Cytokine storm modulation/blockade with oral polyvalent immunoglobulins (PVIG, KMP01D): A potential and safe therapeutic agent (Primum nil nocere)

Laura M. Sly et al.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS (2020)

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Mesenchymal stem cell therapies for COVID-19: Current status and mechanism of action

Somaye Sadeghi et al.

LIFE SCIENCES (2020)

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SARS-CoV-2 infection in farmed minks, associated zoonotic concerns, and importance of the One Health approach during the ongoing COVID-19 pandemic

Khan Sharun et al.

VETERINARY QUARTERLY (2020)

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The role of dysregulated immune responses in COVID-19 pathogenesis

S. Tahaghoghi-Hajghorbani et al.

VIRUS RESEARCH (2020)

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NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients

Ralf Kircheis et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study

Bernadette Schurink et al.

LANCET MICROBE (2020)

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Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy

Dimitrios C. Mastellos et al.

CLINICAL IMMUNOLOGY (2020)

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IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19

Yu Chen et al.

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Convalescent plasma therapy for COVID-19: a tried-and-true old strategy?

Yongzhi Xi

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Considering how biological sex impacts immune responses and COVID-19 outcomes

Eileen P. Scully et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses

Zhixing Zhu et al.

RESPIRATORY RESEARCH (2020)

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Is the kidney a target of SARS-CoV-2?

Miguel Angel Martinez-Rojas et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2020)

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Detection of Novel Coronavirus by RT-PCR in Stool Specimen from Asymptomatic Child, China

An Tang et al.

EMERGING INFECTIOUS DISEASES (2020)

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COVID-19: immunopathogenesis and Immunotherapeutics

Li Yang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome

Luke Adam Monteagudo et al.

ACR OPEN RHEUMATOLOGY (2020)

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A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)

Ying-Hui Jin et al.

MILITARY MEDICAL RESEARCH (2020)

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The Novel Coronavirus: A Bird's Eye View

Parham Habibzadeh et al.

INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2020)

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How COVID-19 induces cytokine storm with high mortality

Shintaro Hojyo et al.

INFLAMMATION AND REGENERATION (2020)

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Is there relationship between SARS-CoV-2 and the complement C3 and C4?

Hamad Dheir et al.

TURKISH JOURNAL OF MEDICAL SCIENCES (2020)

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Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia

Ling Lin et al.

EMERGING MICROBES & INFECTIONS (2020)

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Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis

Thomas J. Bell et al.

MATRIX BIOLOGY (2019)

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Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

Congqing Wu et al.

IMMUNITY (2019)

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Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome

Yaseen M. Arabi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

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Herbal Immunomodulators - A Remedial Panacea for Designing and Developing Effective Drugs and Medicines: Current Scenario and Future Prospects

Ruchi Tiwari et al.

CURRENT DRUG METABOLISM (2018)

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Medicinal and Therapeutic Potential of Herbs and Plant Metabolites / Extracts Countering Viral Pathogens - Current Knowledge and Future Prospects

Kuldeep Dhama et al.

CURRENT DRUG METABOLISM (2018)

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Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Tamas Fulop et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Gut-lung axis: The microbial contributions and clinical implications

Yang He et al.

CRITICAL REVIEWS IN MICROBIOLOGY (2017)

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Emerging pathogenic links between microbiota and the gut-lung axis

Kurtis F. Budden et al.

NATURE REVIEWS MICROBIOLOGY (2017)

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Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

Sarang Tartey et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2017)

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Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

Rudragouda Channappanavar et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

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The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function

Yuewen Ding et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

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Article Microbiology

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

Rudragouda Channappanavar et al.

CELL HOST & MICROBE (2016)

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Pathogenesis of influenza-induced acute respiratory distress syndrome

Kirsty R. Short et al.

LANCET INFECTIOUS DISEASES (2014)

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Coronavirus virulence genes with main focus on SARS-CoV envelope gene

Marta L. De Diego et al.

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Coronavirus-induced ER stress response and its involvement in regulation of coronavirus-host interactions

To Sing Fung et al.

VIRUS RESEARCH (2014)

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Emerging markers in cardiovascular disease: Where does angiotensin-converting enzyme 2 fit in?

Sheila K. Patel et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2013)

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Age-dependent dysregulation of innate immunity

Albert C. Shaw et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS

G. Y. Oudit et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2009)

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Host innate immune receptors and beyond: Making sense of microbial infections

Ken J. Ishii et al.

CELL HOST & MICROBE (2008)

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Symbiotic gut microbes modulate human metabolic phenotypes

Min Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS

J. K. Yang et al.

DIABETIC MEDICINE (2006)

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Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome

TS Li et al.

JOURNAL OF INFECTIOUS DISEASES (2004)

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Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients

N Lee et al.

JOURNAL OF CLINICAL VIROLOGY (2004)

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