Journal
PATHOGENS
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/pathogens10030340
Keywords
adenovirus; hematopoietic stem cell transplant; lymphohistiocytosis; respiratory infection
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Adenovirus infection is rare in adults, but more common in immunocompromised individuals. Patients undergoing allogenic haploidentical hematopoietic stem cell transplantation are at high risk, and prevention, early diagnosis, and treatment continue to pose challenges.
Human adenovirus infection is rare in adult population, except for in immunocompromised individuals. Recipients of allogenic haploidentical hematopoietic stem cell transplantation are reported at high risk for human adenovirus, which is often lethal when it evolves into the disseminated form. Despite existent guidelines, prevention, early diagnosis, and therapeutics remain challenging. Here, we report the case of a fatal evolution of human adenovirus respiratory infection and discuss the actual recommendations to prevent recurrence of this major issue.
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