Journal
FRONTIERS IN MOLECULAR BIOSCIENCES
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2021.649105
Keywords
non-coding RNA; Helicobacter pylori infection; gastric cancer; genetic polymorphisms; chemoresistance
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Funding
- National Natural Science Foundation of China [81773037]
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Gastric cancer, a common malignant tumor of the digestive system, is influenced by genetic, environmental, and microbial factors. Infection of Helicobacter pylori is closely related to the occurrence of gastric cancer, while non-coding RNA plays a crucial role in tumor progression.
Gastric cancer is a common malignant tumor of the digestive system. Its occurrence and development are the result of a combination of genetic, environmental, and microbial factors. Helicobacter pylori infection is a chronic infection that is closely related to the occurrence of gastric tumorigenesis. Non-coding RNA has been demonstrated to play a very important role in the organism, exerting a prominent role in the carcinogenesis, proliferation, apoptosis, invasion, metastasis, and chemoresistance of tumor progression. H. pylori infection affects the expression of non-coding RNA at multiple levels such as genetic polymorphisms and signaling pathways, thereby promoting or inhibiting tumor progression or chemoresistance. This paper mainly introduces the relationship between H. pylori-infected gastric cancer and non-coding RNA, providing a new perspective for gastric cancer treatment.
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