Journal
FRONTIERS IN MOLECULAR BIOSCIENCES
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2021.664241
Keywords
SecYEG translocon; protein transport; YidC; signal recognition particle; SecA; PpiD; FtsY; stress response
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [KO2184/8, KO2184/9 (SPP2002), SFB1381, 403222702, RTG 2202, 278002225]
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The spatial and temporal coordination of protein transport is crucial for bacterial adaptation to different environmental conditions. The SecYEG translocon plays a key role in bacterial protein transport, with its ability to interact with multiple targeting factors, chaperones, and accessory proteins influencing its ability to transport a variety of substrates.
The spatial and temporal coordination of protein transport is an essential cornerstone of the bacterial adaptation to different environmental conditions. By adjusting the protein composition of extra-cytosolic compartments, like the inner and outer membranes or the periplasmic space, protein transport mechanisms help shaping protein homeostasis in response to various metabolic cues. The universally conserved SecYEG translocon acts at the center of bacterial protein transport and mediates the translocation of newly synthesized proteins into and across the cytoplasmic membrane. The ability of the SecYEG translocon to transport an enormous variety of different substrates is in part determined by its ability to interact with multiple targeting factors, chaperones and accessory proteins. These interactions are crucial for the assisted passage of newly synthesized proteins from the cytosol into the different bacterial compartments. In this review, we summarize the current knowledge about SecYEG-mediated protein transport, primarily in the model organism Escherichia coli, and describe the dynamic interaction of the SecYEG translocon with its multiple partner proteins. We furthermore highlight how protein transport is regulated and explore recent developments in using the SecYEG translocon as an antimicrobial target.
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