Journal
FRONTIERS IN MOLECULAR BIOSCIENCES
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2021.647508
Keywords
severe COVID-19; SARS-CoV-2; gut-lung axis; enteric infection; intestinal dysbiosis
Categories
Funding
- National Natural Science Foundation of China [31900069]
- 111 Project [B13003]
- Tsinghua Chunfeng Foundation
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COVID-19 patients commonly experience gastrointestinal symptoms, indicating a close association between the digestive tract and the disease severity. Understanding the role of intestinal microenvironment in COVID-19 immunopathology is crucial for improving disease control. Probiotics show potential as an alternative medicine to prevent or alleviate severe outcomes of COVID-19.
The global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented threat to the human health. A close association of the digestive tract is implied by the high frequency of gastrointestinal syndromes among COVID-19 patients. A better understanding of the role of intestinal microenvironment in COVID-19 immunopathology will be helpful to improve the control of COVID-19 associated morbidity and mortality. This review summarizes the immune responses associated with the severity of COVID-19, the current evidence of SARS-CoV-2 intestinal tropism, and the potential involvement of gut microenvironment in COVID-19 severity. Additionally, we discuss the therapeutic potential of probiotics as an alternative medicine to prevent or alleviate severe COVID-19 outcome.
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