Metaproteomics-An Advantageous Option in Studies of Host-Microbiota Interaction

Gut microbiome contributes to host health by maintaining homeostasis, increasing digestive efficiency, and facilitating the development of the immune system. Manipulating gut microbiota is being recognized as a therapeutic target to manage various chronic diseases. The therapeutic manipulation of the intestinal microbiome is achieved through diet modification, the administration of prebiotics, probiotics, or antibiotics, and more recently, fecal microbiome transplantation (FMT). In this opinion paper, we give a perspective on the current status of application of multi-omics technologies in the analysis of host-microbiota interactions. The aim of this paper was to highlight the strengths of metaproteomics, which integrates with and often relies on other approaches.

Automated summary

The gut microbiome plays a crucial role in maintaining host health by contributing to homeostasis, enhancing digestive efficiency, and aiding in the development of the immune system. Therapeutic manipulation of the gut microbiota through dietary changes, prebiotics, probiotics, and fecal microbiome transplantation is being increasingly recognized. Utilizing multi-omics technologies, particularly metaproteomics, is providing new insights into host-microbiota interactions.