Journal
ANTIOXIDANTS
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/antiox10040624
Keywords
oxidative stress; bio-antioxidant; chain breaking antioxidant activity; structure– activity relationship; synthesis
Funding
- Russian Foundation for Basic Research [19-53-18019 Bolg_a]
- Bulgarian National Science Fund [KP-06-Russia-28]
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Oxidative stress is caused by an increase in reactive oxygen species or a significant decrease in the effectiveness of antioxidant enzymes and nonenzymatic defense. A study compared the chain-breaking antioxidant activity of 40 phenolic antioxidants to investigate their role as modulators of oxidative stress. The research focused on the chemical reactions initiating free radicals and the effects of substituents in the phenolic structure.
Oxidative stress is associated with the increased production of reactive oxygen species or with a significant decrease in the effectiveness of antioxidant enzymes and nonenzymatic defense. The penetration of oxygen and free radicals in the hydrophobic interior of biological membranes initiates radical disintegration of the hydrocarbon tails of the lipids. This process is known as lipid peroxidation, and the accumulation of the oxidation products as peroxides and the aldehydes and acids derived from them are often used as a measure of oxidative stress levels. In total, 40 phenolic antioxidants were selected for a comparative study and analysis of their chain-breaking antioxidant activity, and thus as modulators of oxidative stress. This included natural and natural-like ortho-methoxy and ortho-hydroxy phenols, nine of them newly synthesized. Applied experimental and theoretical methods (bulk lipid autoxidation, chemiluminescence, in silico methods such as density functional theory (DFT) and quantitative structure-activity relationship ((Q)SAR) modeling) were used to clarify their structure-activity relationship. Kinetics of non-inhibited and inhibited lipid oxidation in close connection with inhibitor transformation under oxidative stress is considered. Special attention has been paid to chemical reactions resulting in the initiation of free radicals, a key stage of oxidative stress. Effects of substituents in the side chains and in the phenolic ring of hydroxylated phenols and biphenols, and the concentration were discussed.
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