Journal
ANTIOXIDANTS
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/antiox10040562
Keywords
myeloperoxidase; oxidative burst; NETs; cellular internalization; immune response; cancer; neurodegeneration
Funding
- German Research Foundation [CCRC 2407-360043781, CRC TRR259-397484323]
- Neven-DuMont foundation
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Myeloperoxidase is a signature enzyme of polymorphonuclear neutrophils in mice and humans, playing multiple roles in various cells and tissues. It is involved in cardiovascular diseases, immune responses, cancer development, and neurodegenerative diseases.
Myeloperoxidase is a signature enzyme of polymorphonuclear neutrophils in mice and humans. Being a component of circulating white blood cells, myeloperoxidase plays multiple roles in various organs and tissues and facilitates their crosstalk. Here, we describe the current knowledge on the tissue- and lineage-specific expression of myeloperoxidase, its well-studied enzymatic activity and incoherently understood non-enzymatic role in various cell types and tissues. Further, we elaborate on Myeloperoxidase (MPO) in the complex context of cardiovascular disease, innate and autoimmune response, development and progression of cancer and neurodegenerative diseases.
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