Journal
ANTIOXIDANTS
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/antiox10030485
Keywords
HFpEF; HFrEF; metabolic syndrome; obesity; cardiometabolic HFpEF; hydrogen sulfide therapeutics; hydrogen sulfide; heart failure
Funding
- National Institutes of Health (NIH) [R01HL146098, 1R01 HL146514, 7R01 HL070241, 1R01 HL151398]
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Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that plays a critical role in cardiac and vascular biology by regulating vascular tone, oxidant defenses, and exerting cytoprotective effects. Recent studies have shown that H2S modulates various components of metabolic syndrome and exhibits cardioprotective signaling in heart failure.
Hydrogen sulfide (H2S) is an endogenous, gaseous signaling molecule that plays a critical role in cardiac and vascular biology. H2S regulates vascular tone and oxidant defenses and exerts cytoprotective effects in the heart and circulation. Recent studies indicate that H2S modulates various components of metabolic syndrome, including obesity and glucose metabolism. This review will discuss studies exhibiting H2S -derived cardioprotective signaling in heart failure with reduced ejection fraction (HFrEF). We will also discuss the role of H2S in metabolic syndrome and heart failure with preserved ejection fraction (HFpEF).
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