Journal
ANTIOXIDANTS
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/antiox10040584
Keywords
Hibiscus syriacus L; (Malvaceae); ultraviolet B; reactive oxygen species; endoplasmic reticulum
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Korea government [2018R1D1A1B07045460, 2019R1A6A1A10072987]
- National Research Foundation of Korea [2018R1D1A1B07045460] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The study found that AHs extracted from the flower petals of H. syriacus L. have anti-aging, antioxidant, and anti-melanogenic properties, protecting the skin from UVB-induced photodamage. AHs prevented apoptosis, ER stress, and mtROS production induced by UVB irradiation, effectively preventing skin cell damage.
Anthocyanin-enriched polyphenols from the flower petals of H. syriacus L. (Malvaceae, AHs) possess anti-septic shock, anti-oxidant, and anti-melanogenic properties. However, whether AHs positively or negatively regulate ultraviolet B (UVB)-mediated photoaging and photodamage remains unclear. This study aims to investigate the protective effect of AHs against UVB-induced damage. We examined the photoprotective effects of AHs on UVB-induced apoptosis, endoplasmic reticulum (ER) stress, and mitochondrial reactive oxygen species (mtROS). AHs prevented UVB irradiation-induced apoptosis of HaCaT keratinocytes by inhibiting caspase activation and ROS production. Moreover, AHs restored the survival rate and the hatchability of UVB-irradiated zebrafish larvae without any abnormalities. Furthermore, AHs inhibited UVB-induced ER stress, resulting in a decrease in mtROS production via the stabilization of the mitochondrial membrane potential. Our results indicate that AHs inhibit UVB-induced apoptosis by downregulating total cytosolic ROof cytosolic CaS and ER-mediated mitoROS production in both HaCaT keratinocytes and zebrafish larvae. These findings provide evidence for the applications of AHs to protect skin from UVB-induced photodamage.
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