Journal
BIOMOLECULES
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/biom11050682
Keywords
hydrogen sulfide; respiratory diseases; metabolism processes; signaling pathways
Categories
Funding
- National Natural Science Foundation of China [81802718, U1504817]
- Foundation of Science and Technology Department of Henan Province, China [192102310151, 202102310480]
- Training Program for Young Backbone Teachers of Institution of Higher Learning in Henan Province, China [2020GGJS038]
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Hydrogen sulfide has been widely investigated for its therapeutic potential in respiratory diseases such as obstructive respiratory disease and bronchial asthma. Despite extensive research, a concrete literature review is crucial for future therapeutics. This review provides a comprehensive overview of the effective role of H2S in respiratory diseases and its metabolism processes in the lung.
Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (H2S) is one of the recognized gaseous transmitters involved in an extensive range of cellular functions, and physiological and pathological processes in a variety of diseases, including respiratory diseases. Recently, the therapeutic potential of H2S for respiratory diseases has been widely investigated. H2S plays a vital therapeutic role in obstructive respiratory disease, pulmonary fibrosis, emphysema, pancreatic inflammatory/respiratory lung injury, pulmonary inflammation, bronchial asthma and bronchiectasis. Although the therapeutic role of H2S has been extensively studied in various respiratory diseases, a concrete literature review will have an extraordinary impact on future therapeutics. This review provides a comprehensive overview of the effective role of H2S in respiratory diseases. Besides, we also summarized H2S production in the lung and its metabolism processes in respiratory diseases.
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