Journal
VACCINES
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/vaccines9040354
Keywords
porcine reproductive and respiratory syndrome; receptor; PRRSV; CD163
Categories
Funding
- Agriculture and Food Research Initiative (AFRI) Competitive Grants from the US Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) [2018-67015-28287, 2016-09462]
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This review discusses recent advances and understanding of PRRSV entry into cells, viral pathogenesis in CD163 gene-edited swine, and CD163 as a potential target of receptor-ligand for the control of PRRS.
Cellular receptors play a critical role in viral infection. At least seven cellular molecules have been identified as putative viral entry mediators for porcine reproductive and respiratory syndrome virus (PRRSV). Accumulating data indicate that among these candidates, CD163, a cysteine-rich scavenger receptor on macrophages, is the major receptor for PRRSV. This review discusses the recent advances and understanding of the entry of PRRSV into cells, viral pathogenesis in CD163 gene-edited swine, and CD163 as a potential target of receptor-ligand for the control of PRRS.
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