Journal
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2021.644014
Keywords
antimicrobial; biogenic nanoparticles; Salmonella Typhimurium; multi-resistance; Confocal Raman Microscopy
Funding
- Comision Sectorial de Investigacion Cientifica (CSIC)
- Espacio Interdisciplinario (EI) y Comision Academica de Posgrado (CAP) (Universidad de la Republica, Uruguay)
- Program for the Development of Basic Sciences (PEDECIBA-Quimica)
- Agencia Nacional de Investigacion e Innovacion (ANII)-Uruguay
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Infectious diseases are a major global health issue, primarily due to the development of multi-resistant microorganisms. Salmonella enterica, particularly Salmonella Typhimurium, poses a significant threat to cattle and humans, highlighting the importance of finding alternative therapeutic approaches.
Infectious diseases are one of the most important health problems worldwide, one of the main causes being the development of multi-resistant microorganisms. Likewise, the zoonotic potential of some pathogens and their ability to transfer resistance mechanisms, reduce the therapeutic options in both humans and animals. Salmonella enterica is an important pathogen that affects a wide range of animal species and humans, being Salmonella Typhimurium one of the most frequent serotypes affecting cattle, causing enteritis, diarrhea, and septicemia. The search for alternative therapeutic approaches has gained importance since the emergence of multidrug resistance to antibiotics and periodic outbreaks of salmonellosis. In this sense, the discovery of new drugs and the development of new strategies, such as the use of nanoparticles with antimicrobial activity, are very promising. The aim of this work was the extracellular production of biogenic silver nanoparticles using fungal extracts and the evaluation of their antimicrobial activity against resistant and multi-resistant Salmonella Typhimurium strains. We here demonstrated the potential of the biogenic nanoparticles as effective bacteriostatic and bactericidal agents for use in biomedical applications. In addition, Confocal Raman Microscopy and Atomic Force Microscopy were used to advance the understanding of the antimicrobial mechanism of biogenic nanoparticles against these pathogenic strains, the results of which suggested that the nanoparticles produced damage in several bacterial cell structures.
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