4.7 Review

3D Cancer Models: The Need for a Complex Stroma, Compartmentalization and Stiffness

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Development of a cost-effective automated platform to produce human liver spheroids for basic and applied research

B. Lucendo-Villarin et al.

Summary: Liver disease is a growing global health problem, with liver transplant as the only curative treatment for end-stage liver disease, but donor organs are insufficient. In order to address the limitations of current cell-based models in performance and cost, the authors have developed an automated platform to scale up the production of liver tissue for disease modeling and drug screening.

BIOFABRICATION (2021)

Review Oncology

Squeezing through the microcirculation: survival adaptations of circulating tumour cells to seed metastasis

Julia Perea Paizal et al.

Summary: This passage explores the impact of mechanical constriction on tumor cells during metastasis, including how forces exerted by capillaries may induce adaptive mechanisms in circulating tumor cells (CTCs) to enhance survival and metastatic potential. The study also highlights how advancements in microfluidics have provided insights into the adaptations developed by CTCs in response to mechanical constraints in the microvasculature, and how these forces may trigger dynamic changes towards a more invasive phenotype in the cells. Understanding the dynamic mechanisms adopted by CTCs within the microcirculation could potentially lead to the development of novel therapeutic approaches for metastatic cancers.

BRITISH JOURNAL OF CANCER (2021)

Article Engineering, Biomedical

Hyaluronan-based hydrogels as versatile tumor-like models: Tunable ECM and stiffness with genipin-crosslinking

Sarah Bonnesoeur et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

Article Biochemical Research Methods

Cell-type-specific signaling networks in heterocellular organoids

Xiao Qin et al.

NATURE METHODS (2020)

Article Computer Science, Interdisciplinary Applications

Mechanical properties of 3D tumor spheroids measured by AFM

A. Giannetti et al.

COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING (2020)

Article Biotechnology & Applied Microbiology

Tubuloids derived from human adult kidney and urine for personalized disease modeling

Frans Schutgens et al.

NATURE BIOTECHNOLOGY (2019)

Article Engineering, Biomedical

3D bioprinted mammary organoids and tumoroids in human mammary derived ECM hydrogels

Peter A. Mollica et al.

ACTA BIOMATERIALIA (2019)

Article Oncology

Cancer invasion regulates vascular complexity in a three-dimensional biomimetic model

Judith Pape et al.

EUROPEAN JOURNAL OF CANCER (2019)

Article Medicine, General & Internal

Stroma-Rich Co-Culture Multicellular Tumor Spheroids as a Tool for Photoactive Drugs Screening

Ilya Yakavets et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Review Immunology

The Tumor Immune Contexture of Prostate Cancer

Natasha Vitkin et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Cell Biology

Colorectal cancer spheroid biobanks: multi-level approaches to drug sensitivity studies

Maria Laura De Angelis et al.

CELL BIOLOGY AND TOXICOLOGY (2018)

Review Oncology

Targeting the tumour stroma to improve cancer therapy

Kenneth C. Valkenburg et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Cell & Tissue Engineering

Decellularized Cartilage Directs Chondrogenic Differentiation: Creation of a Fracture Callus Mimetic

Wollis J. Vas et al.

TISSUE ENGINEERING PART A (2018)

Article Cell & Tissue Engineering

Standardizing compression testing for measuring the stiffness of human bone

S. Zhao et al.

BONE & JOINT RESEARCH (2018)

Review Nanoscience & Nanotechnology

Advances in organ-on-a-chip engineering

Boyang Zhang et al.

NATURE REVIEWS MATERIALS (2018)

Article Engineering, Mechanical

Complex mechanics of the heterogeneous extracellular matrix in cancer

Andrea Malandrino et al.

EXTREME MECHANICS LETTERS (2018)

Article Materials Science, Multidisciplinary

3D bioprinting scaffold using alginate/polyvinyl alcohol bioinks

Yongxiang Luo et al.

MATERIALS LETTERS (2017)

Article Multidisciplinary Sciences

Engineering a vascularised 3D in vitro model of cancer progression

Tarig Magdeldin et al.

SCIENTIFIC REPORTS (2017)

Article Engineering, Biomedical

Wide-range stiffness gradient PVA/HA hydrogel to investigate stem cell differentiation behavior

Se Heang Oh et al.

ACTA BIOMATERIALIA (2016)

Article Multidisciplinary Sciences

Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment

Danh Truong et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

Sylvia F. Boj et al.

Article Materials Science, Biomaterials

Fabrication of scalable and structured tissue engineering scaffolds using water dissolvable sacrificial 3D printed moulds

Soumyaranjan Mohanty et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2015)

Article Cell Biology

Beyond 3D culture models of cancer

Kandice Tanner et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Article Biochemical Research Methods

Digital Microfluidics for Automated Hanging Drop Cell Spheroid Culture

Andrew P. Aijian et al.

Review Pharmacology & Pharmacy

The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer

Britta Weigelt et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

Editorial Material Oncology

Pancreatic Cancer Stroma: Friend or Foe?

Jesse Gore et al.

CANCER CELL (2014)

Article Medicine, Research & Experimental

A 3D Biomimetic Model of Tissue Stiffness Interface for Cancer Drug Testing

Chee Ren Ivan Lam et al.

MOLECULAR PHARMACEUTICS (2014)

Review Biochemistry & Molecular Biology

Vascular remodeling in cancer

R. H. Farnsworth et al.

ONCOGENE (2014)

Article Biochemistry & Molecular Biology

Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts

Yuki Kishimoto et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Stiff Collagen Matrices Increase Tumorigenic Prolactin Signaling in Breast Cancer Cells

Craig E. Barcus et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Engineering, Biomedical

Substrate elasticity controls cell proliferation, surface marker expression and motile phenotype in amniotic fluid-derived stem cells

Aleksander Skardal et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2013)

Review Biochemistry & Molecular Biology

In vitro three-dimensional (3D) models in cancer research: An update

Lauren C. Kimlin et al.

MOLECULAR CARCINOGENESIS (2013)

Review Immunology

Innate and adaptive immune cells in the tumor microenvironment

Thomas F. Gajewski et al.

NATURE IMMUNOLOGY (2013)

Article Cell Biology

Wnt activation promotes neuronal differentiation of Glioblastoma

E. Rampazzo et al.

CELL DEATH & DISEASE (2013)

Article Cell & Tissue Engineering

Oxygen diffusion through collagen scaffolds at defined densities: implications for cell survival in tissue models

Umber Cheema et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2012)

Review Engineering, Biomedical

An overview of tissue and whole organ decellularization processes

Peter M. Crapo et al.

BIOMATERIALS (2011)

Review Clinical Neurology

STRUCTURE AND FUNCTION OF THE SKELETAL MUSCLE EXTRACELLULAR MATRIX

Allison R. Gillies et al.

MUSCLE & NERVE (2011)

Review Cell Biology

3D tumour models: novel in vitro approaches to cancer studies

Agata Nyga et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2011)

Article Biochemical Research Methods

Matrigel: A complex protein mixture required for optimal growth of cell culture

Chris S. Hughes et al.

PROTEOMICS (2010)

Review Cell Biology

Navigating ECM Barriers at the Invasive Front: The Cancer Cell-Stroma Interface

R. Grant Rowe et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2009)

Article Multidisciplinary Sciences

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

Catherine A. O'Brien et al.

NATURE (2007)

Review Oncology

Role of tissue stroma in cancer cell invasion

O De Wever et al.

JOURNAL OF PATHOLOGY (2003)

Article Biochemistry & Molecular Biology

Altered content composition and structure of glycosaminoglycans and proteoglycans in gastric carcinoma

AD Theocharis et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2003)