Journal
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2021.630055
Keywords
Alzheheimer’ s disease; pathogenesis; blood brain barrier; nanomedicines; cellular transport; nanoparticles; drug delivery; theranostic
Funding
- National Natural Science Foundation of China [81802718, 81670088]
- Foundation of Science & Technology Department of Henan Province, China [202102310480, 192102310151]
- Training Program for Young Backbone Teachers of Institutions of Higher Learning in Henan Province, China [2020GGJS038]
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Alzheimer's disease is a devastating disease of the aging population characterized by progressive brain decay. Nanomedicines offer advanced alternative approaches to overcome the challenges of drug transport across the blood-brain barrier, revolutionizing the management of AD.
Alzheimer's disease (AD) is a devastating disease of the aging population characterized by the progressive and slow brain decay due to the formation of extracellular plaques in the hippocampus. AD cells encompass tangles of twisted strands of aggregated microtubule binding proteins surrounded by plaques. Delivering corresponding drugs in the brain to deal with these clinical pathologies, we face a naturally built strong, protective barrier between circulating blood and brain cells called the blood-brain barrier (BBB). Nanomedicines provide state-of-the-art alternative approaches to overcome the challenges in drug transport across the BBB. The current review presents the advances in the roles of nanomedicines in both the diagnosis and treatment of AD. We intend to provide an overview of how nanotechnology has revolutionized the approaches used to manage AD and highlight the current key bottlenecks and future perspective in this field. Furthermore, the emerging nanomedicines for managing brain diseases like AD could promote the booming growth of research and their clinical availability.
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