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Metal Material, Properties and Design Methods of Porous Biomedical Scaffolds for Additive Manufacturing: A Review

Journal

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2021.641130

Keywords

metal material; additive manufacturing; porous scaffold; design; bone tissue engineering

Funding

  1. National Science Foundation [51801115]
  2. China Postdoctoral Science Foundation [2020M671112]
  3. High-level Innovation team of basic and Clinical Comprehensive Research on Bone and Joint degenerative Disease, Project of Science and Technology Innovation Base under the Central Guidance of local Science and Technology Development (Guike Jizi [2020]): Sc [198]
  4. Outstanding Scholars Program of Colleges and Universities in Guangxi: innovative team of basic and Clinical Comprehensive Research on Bone and Joint degenerative Disease, Project of Science and Technology Innovation Base under the Central Guidance of local [198]

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Designing an implant similar to human bone remains a critical issue in bone tissue engineering. Metal porous scaffolds show great potential in bone tissue replacement, but traditional processing methods have limitations in fabricating porous structures. With the advancement of additive manufacturing (AM) technologies, new metal materials and innovative design methods have been utilized to develop porous metal scaffolds with excellent mechanical properties and biocompatibility.
Design an implant similar to the human bone is one of the critical problems in bone tissue engineering. Metal porous scaffolds have good prospects in bone tissue replacement due to their matching elastic modulus, better strength, and biocompatibility. However, traditional processing methods are challenging to fabricate scaffolds with a porous structure, limiting the development of porous scaffolds. With the advancement of additive manufacturing (AM) and computer-aided technologies, the development of porous metal scaffolds also ushers in unprecedented opportunities. In recent years, many new metal materials and innovative design methods are used to fabricate porous scaffolds with excellent mechanical properties and biocompatibility. This article reviews the research progress of porous metal scaffolds, and introduces the AM technologies used in porous metal scaffolds. Then the applications of different metal materials in bone scaffolds are summarized, and the advantages and limitations of various scaffold design methods are discussed. Finally, we look forward to the development prospects of AM in porous metal scaffolds.

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