SAXS/WAXS Investigation of Amyloid-β(16-22) Peptide Nanotubes

This brief report presents an X-ray scattering investigation of self-assembled nanotubes formed by a short peptide. X-ray scattering methods enable multiscale structural elucidation of these nanotubes in solution under the same conditions involved in the self-assembly process. In particular, the dimensions of nanotubes and the crystalline organization within their walls can be determined quantitatively. This is illustrated in the case of amyloid-beta(16-22) peptide nanotubes.

Automated summary

This brief report presents an X-ray scattering investigation of self-assembled nanotubes formed by a short peptide, demonstrating the quantitative determination of nanotube dimensions and crystalline organization within their walls, using amyloid-beta(16-22) peptide nanotubes as an illustrative example.