Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.678209
Keywords
ivacaftor; glioblastoma; glioblastoma stem cell; apoptosis; stemness
Categories
Funding
- National Natural Science Foundation of China [U1902216, 81772996]
- Yunnan Applied Basic Research Projects [2019FJ009, 202001AS070037, 2019FB111, 2019HB076, AMHD-2020-3]
- Youth Innovation Promotion Association, CAS
- Yunnan Ten Thousand Talents Plan Young and Elite Talents Project
- Project of Innovative Research Team of Yunnan Province [2019HC005]
Ask authors/readers for more resources
Research has shown that ivacaftor, commonly used for cystic fibrosis therapy, acts as a potent inhibitor of GSCs maintenance in glioblastoma, promoting cellular apoptosis, suppressing patient-derived xenograft tumor growth, and reducing stemness marker gene expressions of GSCs like CD133, CD44, and Sox2, ultimately inhibiting glioblastoma progression.
Glioblastoma (GBM) is the most common and malignant primary brain tumor. Glioblastoma stem cells (GSCs) not only initiate and sustain uncontrolled cell proliferation but also resistant to conventional clinical therapies including temozolomide (TMZ) dependent chemotherapy and radiotherapy, implying that there is an urgent need to identify new therapeutic strategies especially specific targeting GSCs. Here, we provide evidence showing that ivacaftor commonly applied in cystic fibrosis therapy acts as a potent inhibitor for GSCs maintenance. We found that ivacaftor promotes cellular apoptosis in vitro and represses patient-derived xenograft (PDX) tumor growth in vivo. In addition, we demonstrate that ivacaftor decreases stemness marker gene expressions of GSCs, including CD133, CD44, and Sox2. In summary, our findings reveal that ivacaftor inhibits glioblastoma progression via specifically eliminating GSCs, which opens a new avenue for GBM clinical therapy in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available