Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.667581
Keywords
WNT5B; WNT signaling; development; cancer; WNT5A
Categories
Funding
- European Structural and Investment Funds, Operational Programme Research, Development and Education - Preclinical Progression of New Organic Compounds with Targeted Biological Activity (Preclinprogress) [CZ.02.1.01/0.0/0.0/16_025/0007381]
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WNT5B, closely related to WNT5A, plays crucial roles in cell migration, proliferation, and differentiation through the non-canonical pathway. It exhibits unique expression patterns and functions, influencing development, bone, adipose tissue, cardiac tissue, the nervous system, and more. Aberrations in WNT5B signaling contribute to diseases like osteoarthritis, osteoporosis, obesity, diabetes, neuropathology, chronic diseases, and cancers.
WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical beta-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers.
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