Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.680386
Keywords
aging; acer truncatum seed oil; proteomics; learning memory; BDNF
Categories
Funding
- Guangdong Provincial Key ST Program [2018B030336001]
- Sanming Project of Medicine in Shenzhen [SZSM201611090]
Ask authors/readers for more resources
Acer truncatum seed oil treatment significantly improves learning and memory abilities in normal aging mice, activates the BDNF/TrkB signaling pathway, and reduces inflammatory factors expression, suggesting its potential as a therapeutic food supplement for delaying aging.
Aging, characterized by a time-dependent functional decline of physiological integrity, is the major independent risk factor for many neurodegeneration diseases. Therefore, it's necessary to look for natural food supplements to extend the healthy lifespan of aging people. We here treated normal aging mice with acer truncatum seed oil, and found that the seed oil significantly improved the learning and memory ability. Proteomics revealed that the seed oil administration changed many proteins expression involving in biological processes, including complement and coagulation cascades, inflammatory response pathway and innate immune response. BDNF/TrkB signaling pathway was also activated by acer truncatum seed oil treatment. And the seed oil administration increased the expression of postsynaptic related proteins including PSD95, GluA1, and NMDAR1, and decreased the mRNA level of inflammatory factors containing IL-1 beta, TNF-alpha, and IL-6. These findings suggest that acer truncatum seed oil holds a promise as a therapeutic food supplement for delaying aging with multiple mechanisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available