Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.587218
Keywords
polydatin; cervical cancer; c-Myc; cell viability; migration and invasion
Categories
Funding
- National Natural Science Foundation of China [81972357]
- National Training Program of Innovation and Entrepreneurship for Undergraduates [202010635014]
- Natural Science Foundation of Chongqing [cstc2018jcyjAX0330]
- Fundamental Research Funds for the Central Universities [XYDS201912]
- Chongqing Municipal Training Program of Innovation and Entrepreneurship for Undergraduates [S202010635071]
- Southwest University Training Program of Innovation and Entrepreneurship for Undergraduates [X202010635569, X202010635570]
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Polydatin, derived from Polygonum cuspidatum roots, exhibits anti-tumor activity against human cervical cancer by regulating cell cycle-related proteins and epithelial-mesenchymal transition markers, while suppressing the expression of the proto-oncogene c-Myc. Overexpression of c-Myc rescues the inhibitory effect of Polydatin on cell proliferation and metastasis.
Polydatin, an active ingredient from the roots of Polygonum cuspidatum, is considered to have protective effects on the cardiovascular system and liver. In this study, we demonstrated that polydatin has antitumor activity against human cervical cancer. Polydatin efficiently inhibited cervical cancer cell proliferation by regulating cell cycle-related proteins including p21, p27, CDK2, CDK4, Cyclin D1, and Cyclin E1. Furthermore, polydatin suppressed cell invasion and migration by regulating epithelial-mesenchymal transition (EMT) markers, including E-cadherin, N-cadherin, Snail and Slug. The c-Myc, as a proto-oncogene, is considered to be closely associated with the proliferation and metastasis of tumor cells. After polydatin treatment, the protein expression of c-Myc showed a significant decrease. Based on these data, we overexpressed c-Myc in cervical cancer cells and observed that the overexpression of c-Myc rescued the inhibitory effect of polydatin on cell proliferation and metastasis. These results indicated that polydatin can inhibit cell proliferation and metastasis through suppressing the c-Myc expression in human cervical cancer.
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