Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.676364
Keywords
N6-methyladenosine; RNA methylation; spermatogenesis; male fertility; genital system tumors
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Funding
- Funding for Longyuan Young Innovative and Entrepreneurial Talents [842011]
- National Innovation and Entrepreneurship Training Program for Undergraduate [202110730201]
- Hui-Chun Chin and Tsung-Dao Lee Chinese Undergraduate Ressarch Endowment [LZU-JZH2224]
- Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital [CYXZ2019-06]
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Epigenetic alterations, especially RNA methylation, play a crucial role in various diseases, particularly in male infertility and genital system tumors. The biological effects of RNA m6A modification are dynamically regulated by methyltransferases, demethylases, and m6A binding proteins.
Epigenetic alterations, particularly RNA methylation, play a crucial role in many types of disease development and progression. Among them, N6-methyladenosine (m6A) is the most common epigenetic RNA modification, and its important roles are not only related to the occurrence, progression, and aggressiveness of tumors but also affect the progression of many non-tumor diseases. The biological effects of RNA m6A modification are dynamically and reversibly regulated by methyltransferases (writers), demethylases (erasers), and m6A binding proteins (readers). This review summarized the current finding of the RNA m6A modification regulators in male infertility and genital system tumors and discussed the role and potential clinical application of the RNA m6A modification in spermatogenesis and male genital system tumors.
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