Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.640388
Keywords
microenvironment; biomaterial; stem cell therapies; cell behavior; tissue engineering
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Funding
- National Nature Science Foundation of China [81830064, 81721092, 81701906]
- National Key Research and Development Plan [2017YFC1103300]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2019-I2M-5-059]
- Military Medical Research and Development Projects [AWS17J005, 2019-126]
- Fostering Funds of Chinese PLA General Hospital for National Distinguished Young Scholar Science Fund [2017JQPY-002]
- National Natural Science Foundation of China [82002056]
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This review emphasizes the importance of understanding the biophysical and biochemical cues in guiding mesenchymal stem cell (MSC) behaviors, as well as integrating these cues into biomaterials to enhance the prospects of MSC applications.
Mesenchymal stem cells (MSCs) have been widely used in the fields of tissue engineering and regenerative medicine due to their self-renewal capabilities and multipotential differentiation assurance. However, capitalizing on specific factors to precisely guide MSC behaviors is the cornerstone of biomedical applications. Fortunately, several key biophysical and biochemical cues of biomaterials that can synergistically regulate cell behavior have paved the way for the development of cell-instructive biomaterials that serve as delivery vehicles for promoting MSC application prospects. Therefore, the identification of these cues in guiding MSC behavior, including cell migration, proliferation, and differentiation, may be of particular importance for better clinical performance. This review focuses on providing a comprehensive and systematic understanding of biophysical and biochemical cues, as well as the strategic engineering of these signals in current scaffold designs, and we believe that integrating biophysical and biochemical cues in next-generation biomaterials would potentially help functionally regulate MSCs for diverse applications in regenerative medicine and cell therapy in the future.
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