4.7 Article

Distinct antibody and memory B cell responses in SARS-CoV-2 naive and recovered individuals after mRNA vaccination

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

Lauren B. Rodda et al.

Summary: The study found that individuals recovered from mild COVID-19 develop sustained SARS-CoV-2-specific immunological memory for at least 3 months, including immunoglobulin antibodies, neutralizing plasma, and memory B and T cells. These memory lymphocytes exhibit potent antiviral function, aiding in immune defense.
Review Biochemistry & Molecular Biology

Adaptive immunity to SARS-CoV-2 and COVID-19

Alessandro Sette et al.

Summary: The adaptive immune system, consisting of B cells, CD4(+) T cells, and CD8(+) T cells, plays varying roles in different viral infections and vaccines. Studies are showing that CD4(+) T cells, CD8(+) T cells, and neutralizing antibodies all play a part in controlling SARS-CoV-2 in COVID-19 cases, emphasizing the importance of understanding adaptive immunity in combating the disease.
Article Multidisciplinary Sciences

Evolution of antibody immunity to SARS-CoV-2

Christian Gaebler et al.

Summary: After infection with SARS-CoV-2, antibody levels against the spike protein decrease significantly, but the number of memory B cells remain unchanged, indicating an evolving humoral response at 6.2 months after infection.

NATURE (2021)

Letter Medicine, General & Internal

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Alicia T. Widge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

Article Multidisciplinary Sciences

Model-informed COVID-19 vaccine prioritization strategies by age and serostatus

Kate M. Bubar et al.

Summary: The study found that prioritizing the vaccine for adults aged 20 to 49 can minimize the number of cases, while prioritizing the vaccine for adults over 60 can minimize mortality and years of life lost. Redirecting vaccine doses to seronegative individuals through individual-level serological tests can improve the impact of each dose.

SCIENCE (2021)

Article Biochemistry & Molecular Biology

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Wilfredo F. Garcia-Beltran et al.

Summary: New variants of SARS-CoV-2 show high resistance to vaccine neutralization, with some able to escape vaccine responses with just a few mutations, highlighting the importance of developing broadly protective measures against variants.
Article Biochemistry & Molecular Biology

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Daming Zhou et al.

Summary: The race to develop vaccines against SARS-CoV-2 variants, such as B.1.1.7, B.1.351, and P.1, is ongoing as these variants have mutations in the spike protein, potentially leading to immune escape. A structure-function analysis of B.1.351 revealed tighter ACE2 binding and widespread evasion from monoclonal antibody neutralization, particularly driven by the E484K mutation.
Article Infectious Diseases

Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021

Kamal Abu Jabal et al.

Summary: An analysis of 514 Israeli healthcare workers showed that the BNT162b2 mRNA COVID-19 vaccine had similar immunogenicity by ethnicity and sex, but decreased with age. Individuals with prior COVID-19 infection had significantly higher antibody titres compared to those who were naive, regardless of pre-vaccination IgG levels.

EUROSURVEILLANCE (2021)

Article Multidisciplinary Sciences

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier et al.

Summary: The B.1.1.7 variant of SARS-CoV-2 exhibited reduced neutralization by vaccines and antibodies from recovered COVID-19 patients, with a more substantial loss seen when introducing the E484K mutation. This mutation poses a threat to the efficacy of the BNT162b2 vaccine.

NATURE (2021)

Article Immunology

Prolonged evolution of the human B cell response to SARS-CoV-2 infection

Mrunal Sakharkar et al.

Summary: The study on the kinetics and evolution of the human B cell response to SARS-CoV-2 infection revealed that serum neutralizing antibody responses declined rapidly, while spike-specific IgG(+) memory B cells remained stable or increased over time. The research also showed evidence for prolonged antibody affinity maturation and the impact of mutations in the S protein on the neutralizing antibody response.

SCIENCE IMMUNOLOGY (2021)

Article Medicine, Research & Experimental

IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity

Mayara Garcia de Mattos Barbosa et al.

Summary: Neutralizing antibodies against SARS-CoV-2 are considered to be the most immediate and effective treatment for severely afflicted individuals. Broadly neutralizing antibodies are especially sought due to the potential diversification of the coronavirus through mutations. A study reported a novel approach to rapidly generate potent broadly neutralizing human anti-SARS-CoV-2 antibodies, isolating spike protein-specific memory B cells from convalescent individuals and expressing them as human monoclonal antibodies. All 43 generated human monoclonal antibodies neutralized SARS-CoV-2, with some showing high potency against spike-pseudotyped virus and variants, suggesting potential resistance to immunity evoked by infection or vaccines developed based on the Wuhan Hu-1 strain.

JCI INSIGHT (2021)

Article Immunology

The first 12 months of COVID-19: a timeline of immunological insights

Thiago Carvalho et al.

Summary: The timeline of major scientific discoveries during the first year of the COVID-19 pandemic highlights the collaborative efforts that led to rapid progress in understanding the immune response to SARS-CoV-2. It showcases the unprecedented convergence of research efforts on COVID-19 and identifies gaps in knowledge for future investigations.

NATURE REVIEWS IMMUNOLOGY (2021)

Review Immunology

Viral targets for vaccines against COVID-19

Lianpan Dai et al.

Summary: The urgent need for vaccines to control the COVID-19 pandemic has led to the rapid development of multiple vaccine candidates, with some showing positive results in late-stage clinical trials. This article discusses the viral elements used in these candidates, the reasons why they are good targets for the immune system, and their implications for protective immunity. Dai and Gao highlight the importance of selecting the right viral targets in vaccine development to ensure an effective immune response and the overall safety and efficacy of the vaccine.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Immunology

Comprehensive mapping of immune perturbations associated with severe COVID-19

Leticia Kuri-Cervantes et al.

SCIENCE IMMUNOLOGY (2020)

Article Immunology

SARS-CoV-2 seroprevalence among parturient women in Philadelphia

Dustin D. Flannery et al.

SCIENCE IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

Mark J. Mulligan et al.

NATURE (2020)

Article Multidisciplinary Sciences

Human germinal centres engage memory and naive B cells after influenza vaccination

Jackson S. Turner et al.

NATURE (2020)

Article Multidisciplinary Sciences

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Ugur Sahin et al.

NATURE (2020)

Review Immunology

B cell memory: building two walls of protection against pathogens

Munir Akkaya et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Immunology

Computational Evaluation of B-Cell Clone Sizes in Bulk Populations

Aaron M. Rosenfeld et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Biotechnology & Applied Microbiology

An atlas of B-cell clonal distribution in the human body

Wenzhao Meng et al.

NATURE BIOTECHNOLOGY (2017)

Article Biochemistry & Molecular Biology

ETE 3: Reconstruction, Analysis, and Visualization of Phylogenomic Data

Jaime Huerta-Cepas et al.

MOLECULAR BIOLOGY AND EVOLUTION (2016)

Review Immunology

Memory B cells

Tomohiro Kurosaki et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Biochemical Research Methods

pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires

Jason A. Vander Heiden et al.

BIOINFORMATICS (2014)

Article Biochemistry & Molecular Biology

IgBLAST: an immunoglobulin variable domain sequence analysis tool

Jian Ye et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Multidisciplinary Sciences

Vaccine-Induced Boosting of Influenza Virus-Specific CD4 T Cells in Younger and Aged Humans

Douglas V. Dolfi et al.

PLOS ONE (2013)

Review Immunology

Molecular programming of B cell memory

Michael McHeyzer-Williams et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Article Immunology

Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants

Whitney E. Purtha et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Review Immunology

B-cell responses to vaccination at the extremes of age

Claire-Anne Siegrist et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Article Medicine, General & Internal

Duration of humoral immunity to common viral and vaccine antigens

Ian J. Amanna et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Review Biochemistry & Molecular Biology

Somatic hypermutation of immunoglobulin genes: Merging mechanisms for genetic diversity

FN Papavasiliou et al.