Monitoring the proportion of the population infected by SARS-CoV-2 using age-stratified hospitalisation and serological data: a modelling study

Article Medicine, General & Internal

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

S. F. Lumley et al.

Summary: In a longitudinal study of seropositive and seronegative health care workers undergoing asymptomatic and symptomatic SARS-CoV-2 testing, the presence of anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

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Article Public, Environmental & Occupational Health

Community prevalence of SARS-CoV-2 in England from April to November, 2020: results from the ONS Coronavirus Infection Survey

Koen B. Pouwels et al.

Summary: This study in England found significant changes in the number of individuals testing positive for SARS-CoV-2 and risk factors for positivity over time from April to November 2020. Important risk factors for testing positive varied between the first and second waves, with age being a key driver of increased positivity rates in the second wave. Continued monitoring for SARS-CoV-2 in the community will be important for managing the COVID-19 pandemic moving forwards.

LANCET PUBLIC HEALTH (2021)

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Letter Immunology

Severe Reinfection With South African Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variant 501Y.V2

Noemie Zucman et al.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Infectious Diseases

Do not neglect SARS-CoV-2 hospitalization and fatality risks in the middle-aged adult population

Nathanael Lapidus et al.

Summary: The study in France estimated the SARS-CoV-2 infection hospitalization ratio (IHR) and infection fatality ratio (IFR), which increased with age, especially in men and the elderly. The findings suggest the need for comprehensive preventive measures to reduce virus transmission, even in young or middle-aged adults.

INFECTIOUS DISEASES NOW (2021)

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Article Medicine, General & Internal