Journal
SCIENCE ROBOTICS
Volume 6, Issue 52, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scirobotics.abd2813
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Funding
- Hong Kong RGC Joint Laboratory Funding Scheme (JLFS) [JLFS/E-402/18]
- Hong Kong ITC [MRP/036/18X, ITS/440/17FP, ITS/374/18FP]
- CUHK internal grants
- SIAT-CUHK Joint Laboratory of Robotics and Intelligent Systems
- Impact Postdoctoral Fellowship Scheme from the Chinese University of Hong Kong
- Multi-Scale Medical Robotics Center (MRC), InnoHK, at the Hong Kong Science Park
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The study introduces a soft and resilient magnetic cell microrobot with high biocompatibility for navigation inside the human body. It demonstrates efficient delivery of soft microrobots through the integrated platform called endoscopy-assisted magnetic actuation with dual imaging system (EMADIS), allowing access to tiny regions deep within the body that are commonly inaccessible by traditional endoscopes and medical robots.
High-precision delivery of microrobots at the whole-body scale is of considerable importance for efforts toward targeted therapeutic intervention. However, vision-based control of microrobots, to deep and narrow spaces inside the body, remains a challenge. Here, we report a soft and resilient magnetic cell microrobot with high biocompatibility that can interface with the human body and adapt to the complex surroundings while navigating inside the body. We achieve time-efficient delivery of soft microrobots using an integrated platform called endoscopyassisted magnetic actuation with dual imaging system (EMADIS). EMADIS enables rapid deployment across multiple organ/tissue barriers at the whole-body scale and high-precision delivery of soft and biohybrid microrobots in real time to tiny regions with depth up to meter scale through natural orifice, which are commonly inaccessible and even invisible by conventional endoscope and medical robots. The precise delivery of magnetic stem cell spheroid microrobots (MSCSMs) by the EMADIS transesophageal into the bile duct with a total distance of about 100 centimeters can be completed within 8 minutes. The integration strategy offers a full clinical imaging technique? based therapeutic/intervention system, which broadens the accessibility of hitherto hard-to-access regions, by means of soft microrobots.
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