Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 8, Issue 8, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofab153
Keywords
COVID-19; remdesivir; SARS-CoV-2; viral kinetics; viral load
Categories
Funding
- US Department of Energy [89233218CNA000001]
- Los Alamos National Laboratory [20210730]
- National Science Foundation RAPID Grant [PHY-2031756]
- National Institute of Health [R01-AI028433, R01-OD011095]
- National Science Foundation [DMS-1714654]
- National Institutes of Health [R01-OD011095, R21-AI143443-01A1]
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The dynamics of SARS-CoV-2 remain understudied, but early systemic seeding of the virus was observed in hospitalized individuals. Remdesivir treatment was associated with faster viral decay in the body.
Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.
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