4.4 Article

Limited Index of Clinical Suspicion and Underdiagnosis of Histopathologically Documented Invasive Mold Infections

Journal

OPEN FORUM INFECTIOUS DISEASES
Volume 8, Issue 7, Pages -

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofab174

Keywords

aspergillosis; autopsy; biopsy; lymphoma; mucormycosis; mycelia; solid tumor

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Invasive mold infections are challenging to diagnose, with a particularly high rate of missed diagnosis among nonhematologic cancer patients.
Invasive mold infections (IMIs) are difficult to diagnose. This analysis of histopathologically proven IMIs at our institution (2010-2019) showed that 11/41 (27%) of them were not suspected at the time of biopsy/autopsy (9/17, 53% among autopsies). The rate of missed diagnosis was particularly high (8/16, 50%) among nonhematologic cancer patients.

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