Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.675940
Keywords
small extracellular vesicles (sEVs); exosomes; membrane protein; biomarker; diagnosis; targeted therapy
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Funding
- National Natural Science Foundation of China [81702580]
- Key R&D Planning Project of Jiangxi Science and Technology Commission, China [20203BBGL73126]
- Creative Research Groups of Gannan Medical University, China [TD201704]
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Small extracellular vesicles carry membrane proteins with cell-specific signatures that can be used as biomarkers and target proteins for disease diagnosis and treatment. This article classifies and summarizes the pathophysiological functions of small extracellular vesicle membrane proteins in disease management.
Small extracellular vesicles are membrane-bound vesicles secreted into extracellular spaces by virtually all types of cells. These carry a large number of membrane proteins on their surface that are incorporated during their biogenesis in cells. The composition of the membrane proteins hence bears the signature of the cells from which they originate. Recent studies have suggested that the proteins on these small extracellular vesicles can serve as biomarkers and target proteins for the diagnosis and treatment of diseases. This article classifies small extracellular vesicle membrane proteins and summarizes their pathophysiological functions in the diagnosis and treatment of diseases.
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