Advances in Rodent Models for Breast Cancer Formation, Progression, and Therapeutic Testing

Breast cancer is a highly complicated disease. Advancement in the treatment and prevention of breast cancer lies in elucidation of the mechanism of carcinogenesis and progression. Rodent models of breast cancer have developed into premier tools for investigating the mechanisms and genetic pathways in breast cancer progression and metastasis and for developing and evaluating clinical therapeutics. Every rodent model has advantages and disadvantages, and the selection of appropriate rodent models with which to investigate breast cancer is a key decision in research. Design of a suitable rodent model for a specific research purpose is based on the integration of the advantages and disadvantages of different models. Our purpose in writing this review is to elaborate on various rodent models for breast cancer formation, progression, and therapeutic testing.

Automated summary

Breast cancer is a highly complex disease, and advancements in treatment and prevention depend on understanding the mechanisms of carcinogenesis and progression. Rodent models have become crucial tools for investigating breast cancer progression and metastasis, but the selection of suitable models is key due to their various advantages and disadvantages. Designing a rodent model for specific research purposes involves integrating the pros and cons of different models.