Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.667428
Keywords
prognosis; diagnosis; biomarker; circular RNA; hepatocellular carcinoma
Categories
Funding
- National Natural Science Foundation of China [81702896]
- Science and Technology Plan Projects of Jilin Province [20200201539JC]
- Department of Education of Jilin Province [JJKH20180198KJ]
- China Scholarship Council [201706175044, 201606175202]
- Jilin University Project [2019YX396]
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Circular RNAs (circRNAs) are a class of non-coding RNAs with closed loop structures, characterized by stability and regulatory roles. Dysregulated expression of circRNAs in HCC is associated with tumor hallmarks, cancer stemness, and immunotherapy. CircRNAs have potential as biomarkers and therapeutic targets for HCC.
Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver and carries high morbidity and mortality. Diagnosing HCC at an early stage is challenging. Therefore, finding new, highly sensitive and specific diagnostic biomarkers for the diagnosis and prognosis of HCC patients is extremely important. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently closed loop structures. They are characterized by remarkable stability, long half-life, abundance and evolutionary conservation. Recent studies have shown that many circRNAs are expressed aberrantly in HCC tissues and have important regulatory roles during the development and progression of HCC. Hence, circRNAs are promising biomarkers for the diagnosis and prognosis of HCC. This review: (i) summarizes the biogenesis, categories, and functions of circRNAs; (ii) focuses on current progress of dysregulated expression of circRNAs in HCC with regard to regulation of the tumor hallmarks, stemness of cancer cells, and immunotherapy; (iii) highlights circRNAs as potential biomarkers and therapeutic targets for HCC; and (iv) discusses some of the challenges, questions and future perspectives of circRNAs research in HCC.
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