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Gonadotropin-Releasing Hormone Receptor Signaling: Biased and Unbiased
C. A. McArdle
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2012)
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Christopher E. Barbieri et al.
NATURE GENETICS (2012)
Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy
Howard I. Scher et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Androgen receptor and its splice variants in prostate cancer
Simon Haile et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2011)
Resistance to CYP17A1 Inhibition with Abiraterone in Castration-Resistant Prostate Cancer: Induction of Steroidogenesis and Androgen Receptor Splice Variants
Elahe A. Mostaghel et al.
CLINICAL CANCER RESEARCH (2011)
Novel agents and new therapeutics in castration-resistant prostate cancer
Yichao Wu et al.
CURRENT OPINION IN ONCOLOGY (2011)
Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy
Changmeng Cai et al.
ENDOCRINE-RELATED CANCER (2011)
被撤回的出版物: Gq Protein-induced Apoptosis Is Mediated by AKT Kinase Inhibition That Leads to Protein Kinase C-induced c-Jun N-terminal Kinase Activation (Retracted article. See vol. 292, pg. 8848, 2017)
Ido Ben-Ami et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Efficacy of a Second Line Luteinizing Hormone-Releasing Hormone Agonist After Advanced Prostate Cancer Biochemical Recurrence
Nathan Lawrentschuk et al.
JOURNAL OF UROLOGY (2011)
Abiraterone and Increased Survival in Metastatic Prostate Cancer
Johann S. De Bono et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival
Emma Hornberg et al.
PLOS ONE (2011)
Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases
Xiaotun Zhang et al.
PLOS ONE (2011)
Elevated GnRH Receptor Expression Plus GnRH Agonist Treatment Inhibits the Growth of a Subset of Papillomavirus 18-Immortalized Human Prostate Cells
Kevin Morgan et al.
PROSTATE (2011)
Integrative Genomic Profiling of Human Prostate Cancer
Barry S. Taylor et al.
CANCER CELL (2010)
Dual Targeting of Tumor and Endothelial Cells by Gonadotropin-Releasing Hormone Agonists to Reduce Melanoma Angiogenesis
Roberta M. Moretti et al.
ENDOCRINOLOGY (2010)
Additional Analysis of the Secondary End Point of Biochemical Recurrence Rate in a Phase 3 Trial (CS21) Comparing Degarelix 80 mg Versus Leuprolide in Prostate Cancer Patients Segmented by Baseline Characteristics
Bertrand Tombal et al.
EUROPEAN UROLOGY (2010)
Systematic Structure-Function Analysis of Androgen Receptor Leu701 Mutants Explains the Properties of the Prostate Cancer Mutant L701H
Dennis J. van de Wijngaart et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
Shihua Sun et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Use of Analogs of Peptide Hormones Conjugated to Cytotoxic Radicals for Chemotherapy Targeted to Receptors on Tumors
Andrew V. Schally et al.
Current Drug Delivery (2010)
Gonadotropin-releasing hormone type II antagonist induces apoptosis in MCF-7 and triple-negative MDA-MB-231 human breast cancer cells in vitro and in vivo
Carsten Gruendker et al.
BREAST CANCER RESEARCH (2010)
Review of Major Adverse Effects of Androgen-deprivation Therapy in Men With Prostate Cancer
Lockwood G. Taylor et al.
CANCER (2009)
Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy
Mara P. Steinkamp et al.
CANCER RESEARCH (2009)
GnRH-II Antagonists Induce Apoptosis in Human Endometrial, Ovarian, and Breast Cancer Cells via Activation of Stress-induced MAPKs p38 and JNK and Proapoptotic Protein Bax
Stefanie Fister et al.
CANCER RESEARCH (2009)
Aberrant Activation of Androgen Receptor in a New Neuropeptide-Autocrine Model of Androgen-Insensitive Prostate Cancer
Joy C. Yang et al.
CANCER RESEARCH (2009)
Fluorescence In situ Hybridization Analysis of Circulating Tumor Cells in Metastatic Prostate Cancer
Margaret A. Leversha et al.
CLINICAL CANCER RESEARCH (2009)
Luteinizing hormone-releasing hormone antagonists
Gabor Mezoe et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2009)
Signaling by G-protein-coupled receptor (GPCR): Studies on the GnRH receptor
Zvi Naor
FRONTIERS IN NEUROENDOCRINOLOGY (2009)
Type I Gonadotropin-Releasing Hormone Receptor Mediates the Antiproliferative Effects of GnRH-II on Prostate Cancer Cells
Marina Montagnani Marelli et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)
Increased Expression of Androgen Receptor Coregulator MAGE-11 in Prostate Cancer by DNA Hypomethylation and Cyclic AMP
Adam R. Karpf et al.
MOLECULAR CANCER RESEARCH (2009)
Luteinizing hormone-releasing hormone receptor-targeted deslorelin-docetaxel conjugate enhances efficacy of docetaxel in prostate cancer therapy
Sneha Sundaram et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Human gonadotropin-releasing hormone receptor-activated cellular functions and signaling pathways in extra-pituitary tissues and cancer cells (Review)
Arturo Aguilar-Rojas et al.
ONCOLOGY REPORTS (2009)
Gonadotropin Releasing Hormone Analogs Induce Apoptosis by Extrinsic Pathway Involving p53 Phosphorylation in Primary Cell Cultures of Human Prostatic Adenocarcinomas
Marisa Clementi et al.
PROSTATE (2009)
DEGARELIX ACETATE FOR THE TREATMENT OF PROSTATE CANCER
Laurence Klotz
DRUGS OF TODAY (2009)
Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family
Jianming Xu et al.
NATURE REVIEWS CANCER (2009)
The efficacy and safety of degarelix: a 12-month, comparative, randomized, open-label, parallel-group phase III study in patients with prostate cancer
Laurence Klotz et al.
BJU INTERNATIONAL (2008)
Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
R. Bruce Montgomery et al.
CANCER RESEARCH (2008)
Androgen deprivation therapy for prostate cancer
Eric A. Singer et al.
EXPERT OPINION ON PHARMACOTHERAPY (2008)
Gonadotropin-releasing hormone and ovarian cancer: a functional and mechanistic overview
Wai-Kin So et al.
FEBS JOURNAL (2008)
Diversity of actions of GnRHs mediated by ligand-induced selective signaling
Robert P. Millar et al.
FRONTIERS IN NEUROENDOCRINOLOGY (2008)
Gonadotropin-releasing hormone II: a multi-purpose neuropeptide
Johanna S. Schneider et al.
INTEGRATIVE AND COMPARATIVE BIOLOGY (2008)
Androgen receptor (AR) coregulators: A diversity of functions converging on and regulating the AR transcriptional complex
Hannelore V. Heemers et al.
ENDOCRINE REVIEWS (2007)
Expression of GnRH type II is regulated by the androgen receptor in prostate cancer
S. Darby et al.
ENDOCRINE-RELATED CANCER (2007)
Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice
Arthur C-K. Chung et al.
CANCER RESEARCH (2007)
Structure-activity study on the LH- and FSH-releasing and anticancer effects of gonadotropin-releasing hormone (GnRH)-III analogs
Magdolna Kovacs et al.
PEPTIDES (2007)
Expression of vascular endothelial growth factor (VEGF) in locally invasive prostate cancer is prognostic for radiotherapy outcome
Melanie M. L. Green et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2007)
Prostate cancer cells increase androgen sensitivity by increase in nuclear androgen receptor and androgen receptor coactivators; A possible mechanism of hormone-resistance of prostate cancer cells
Naohiro Fujimoto et al.
CANCER INVESTIGATION (2007)
Gonadotropin-releasing hormone (GnRH) receptors in tumors: a new rationale for the therapeutical application of GnRH analogs in cancer patients?
M. Montagnani Marelli et al.
CURRENT CANCER DRUG TARGETS (2006)
Effect of leuprolide and cetrorelix on cell growth, apoptosis, and GnRH receptor expression in primary cell cultures from human prostate carcinoma
E Castellón et al.
CANCER INVESTIGATION (2006)
Gonadotropin-releasing hormone in apoptosis of prostate cancer cells
S Kraus et al.
CANCER LETTERS (2006)
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
M Stanbrough et al.
CANCER RESEARCH (2006)
Mechanism of gonadotropin-releasing hormone (GnRH)-I and -II-induced cell growth inhibition in ovarian cancer cells: role of the GnRH-I receptor and protein kinase C pathway
KY Kim et al.
ENDOCRINE-RELATED CANCER (2006)
Gonadotropin-releasing hormone induces actin cytoskeleton remodeling and affects cell migration in a cell-type-specific manner in TSU-Pr1 and DU145 cells
M Enomoto et al.
ENDOCRINOLOGY (2006)
Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis
SY Wong et al.
CANCER RESEARCH (2005)
Immunohistochemical demonstration of gonadotropin-releasing hormone receptors in prostate carcinoma
J Szabó et al.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2005)
Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking
QB Wang et al.
MOLECULAR CELL (2005)
GnRHs and GnRH receptors
RP Millar
ANIMAL REPRODUCTION SCIENCE (2005)
Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
MA Titus et al.
CLINICAL CANCER RESEARCH (2005)
Differential effects of gonadotropin-releasing hormone (GnRH)-I and GnRH-II on prostate cancer cell signaling and death
K Maiti et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Evidence that prostate gonadotropin-releasing hormone receptors mediate an anti-tumourigenic response to analogue therapy in hormone refractory prostate cancer
VJ Gnanapragasam et al.
JOURNAL OF PATHOLOGY (2005)
Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-1I, and their receptors in humans
CK Cheng et al.
ENDOCRINE REVIEWS (2005)
Luteinising hormone-releasing hormone analogue reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline
C Yates et al.
BRITISH JOURNAL OF CANCER (2005)
Chemistry and structural biology of androgen receptor
WQ Gao et al.
CHEMICAL REVIEWS (2005)
Gonadotropin-releasing hormone receptors
RP Millar et al.
ENDOCRINE REVIEWS (2004)
Gonadotropin-releasing hormone induces apoptosis of prostate cancer cells:: Role of c-Jun NH2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways
S Kraus et al.
CANCER RESEARCH (2004)
Gonadotropin-releasing hormone and its receptor in normal and malignant cells
GS Harrison et al.
ENDOCRINE-RELATED CANCER (2004)
Antiproliferative effects of the GnRH antagonist cetrorelix and of GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I receptor
C Gründker et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2004)
Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Gαi-coupling state of the type I GnRH receptor
S Maudsley et al.
CANCER RESEARCH (2004)
Newly recognized GnRH receptors: function and relative role
JD Neill et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2004)
Androgen receptor mutations in androgen-in dependent prostate cancer: Cancer and Leukemia Group B Study 9663
ME Taplin et al.
JOURNAL OF CLINICAL ONCOLOGY (2003)
Inhibitory activity of luteinizing hormone-releasing hormone on tumor growth and progression
RM Moretti et al.
ENDOCRINE-RELATED CANCER (2003)
A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12
K Morgan et al.
ENDOCRINOLOGY (2003)
The role of angiogenesis in prostate development and the pathogenesis of prostate cancer
D Hrouda et al.
UROLOGICAL RESEARCH (2003)
Signalling and anti-proliferative effects mediated by gonadotrophin-releasing hormone receptors after expression in prostate cancer cells using recombinant adenovirus
J Franklin et al.
JOURNAL OF ENDOCRINOLOGY (2003)
GnRH II and type II GnRH receptors
RP Millar
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2003)
Type II gonadotropin-releasing hormone receptor transcripts in human sperm
W van Biljon et al.
BIOLOGY OF REPRODUCTION (2002)
Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells
T Ueda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Can combined androgen blockade provide long-term control or possible cure of localized prostate cancer?
F Labrie et al.
UROLOGY (2002)
Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors
CA McArdle et al.
JOURNAL OF ENDOCRINOLOGY (2002)
Biology of the gonadotropin-releasing hormone system in gynecological cancers
C Grundker et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2002)
Nuclear receptor coregulators: multiple modes of modification
O Hermanson et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2002)
Intracellular signaling pathways mediated by the gonadotropin-releasing hormone (GnRH) receptor
S Kraus et al.
ARCHIVES OF MEDICAL RESEARCH (2001)
Hypothalamic hormones and cancer
AV Schally et al.
FRONTIERS IN NEUROENDOCRINOLOGY (2001)
Expression of the second isoform of gonadotrophin-releasing hormone (GnRH-II) in human endometrium throughout the menstrual cycle
KW Cheon et al.
MOLECULAR HUMAN REPRODUCTION (2001)
LHRH analogues as anticancer agents: pituitary and extrapituitary sites of action
P Limonta et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2001)
Androgen receptor gene amplification at primary progression predicts response to combined androgen blockade as second line therapy for advanced prostate cancer
C Palmberg et al.
JOURNAL OF UROLOGY (2000)
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
XY Zhao et al.
NATURE MEDICINE (2000)
High incidence of receptors for luteinizing hormone-releasing hormone (LHRH) and LHRH receptor gene expression in human prostate cancers
G Halmos et al.
JOURNAL OF UROLOGY (2000)
Expression of the insulin-like growth factor system and cancer progression in hormone-treated prostate cancer patients
K Mita et al.
INTERNATIONAL JOURNAL OF UROLOGY (2000)