Journal
CELLS
Volume 10, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/cells10051134
Keywords
inflammation; type I interferons; interleukin-1β crosstalk
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Funding
- Agence Nationale de la Recherche (ANR) [ANR-11LABX-0070_TRANSPLANTEX]
- Institut National de la Sante et de la Recherche Medicale (INSERM), MSD-Avenir grant AUTOGEN
- University of Strasbourg (including IDEX UNISTRA)
- European regional development fund (European Union)
- Federation Hospitalo-Universitaire (FHU) OMICARE
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This review examines the roles of IL-1 beta and type I IFNs in autoinflammatory/rheumatic diseases and analyzes their potential connections in the pathophysiology of some of these diseases, providing new therapeutic opportunities.
Interleukin-1 beta (IL-1 beta) and type I interferons (IFNs) are major cytokines involved in autoinflammatory/autoimmune diseases. Separately, the overproduction of each of these cytokines is well described and constitutes the hallmark of inflammasomopathies and interferonopathies, respectively. While their interaction and the crosstalk between their downstream signaling pathways has been mostly investigated in the frame of infectious diseases, little information on their interconnection is still available in the context of autoinflammation promoted by sterile triggers. In this review, we will examine the respective roles of IL-1 beta and type I IFNs in autoinflammatory/rheumatic diseases and analyze their potential connections in the pathophysiology of some of these diseases, which could reveal novel therapeutic opportunities.
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