4.6 Article

Metabolite Biomarkers of Leishmania Antimony Resistance

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Summary: The study used lipidomic profiles to differentiate between sensitive and resistant Leishmania strains, showing that resistant phenotypes had downregulated phosphatidylcholines, decreased sphingolipids, and increased lysophosphatidylcholines, while sensitive phenotypes had upregulated triglycerides and decreased phosphatidylethanolamine. The changes in lipid composition in antimony-resistant parasites appear to contribute to their physiological response to combat oxidative stress caused by the drug, highlighting several lipids as potential biomarkers for drug resistance.

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