Journal
CELLS
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/cells10030661
Keywords
fusion; autosome; hexavalent; sex-chromosome turnover
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [19K06788]
- Ministry of Science and Technology, Taiwan [MOST 108-2621-B-003-003-MY3]
- Grants-in-Aid for Scientific Research [19K06788] Funding Source: KAKEN
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Translocations between sex chromosomes and autosomes can generate multiple sex chromosome systems. In a Taiwanese brown frog, a unique multiple sex chromosome system was discovered, involving three different chromosome pairs with translocations occurring among potential sex-determining chromosomes, including orthologs of sex-determining genes in various vertebrates. This rare case suggests sex-specific, nonrandom translocations, shedding light on the evolutionary significance of multiple sex chromosome systems.
Translocation between sex-chromosomes and autosomes generates multiple sex-chromosome systems. It happens unexpectedly, and therefore, the evolutionary meaning is not clear. The current study shows a multiple sex chromosome system comprising three different chromosome pairs in a Taiwanese brown frog (Odorrana swinhoana). The male-specific three translocations created a system of six sex-chromosomes, male X1Y1X2Y2X3Y3-female X1X1X2X2X3X3. It is unique in that the translocations occurred among three out of the six members of potential sex-determining chromosomes, which are known to be involved in sex-chromosome turnover in frogs, and the two out of three include orthologs of the sex-determining genes in mammals, birds and fishes. This rare case suggests sex-specific, nonrandom translocations and thus provides a new viewpoint for the evolutionary meaning of the multiple sex chromosome system.
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